Makinskiĭ A I, Ivan'ko T P, Makarova V V, Polozov A I
Probl Tuberk. 1991(8):39-42.
The basic mechanisms responsible for equilibrium impairment in the hemostatic system in pulmonary tuberculosis patients are reduced activity of antithrombin III and disturbances of platelet functional capacities. These changes were proved to reflect the course of intravascular hemocoagulation whose degree of manifestation is related directly to the extent of specific lesions in the lungs and intoxication phenomena. The process of intravascular hemocoagulation in tuberculosis patients runs in the presence of an increased concentration of plasma fibronectin , while major surgery performed in patients with fibrous-cavernous processes leads to its reduced level. It is pathogenetically proved to use antithrombin III concentrate preparations with anti- and dysaggregatory properties, fibronectin preparations, trasylol or its analogs during complex preoperative preparation of patients.
肺结核患者止血系统平衡受损的基本机制是抗凝血酶III活性降低和血小板功能能力紊乱。这些变化被证明反映了血管内凝血过程，其表现程度与肺部特异性病变的范围和中毒现象直接相关。肺结核患者的血管内凝血过程在血浆纤连蛋白浓度升高的情况下发生，而在纤维空洞型肺结核患者进行大手术时会导致其水平降低。从发病机制上证明，在患者的复杂术前准备过程中使用具有抗聚集和抗解聚特性的抗凝血酶III浓缩制剂、纤连蛋白制剂、抑肽酶或其类似物。
