卡马西平的多晶型：卡马西平二水合物的固态研究

Polymorphism of carbamazepine: solid-state studies on carbamazepine dihydrate.

作者信息

Dugué J, Céolin R, Rouland J C, Lepage F

机构信息

Laboratoire de Chimie Minérale Structurale, (CNRS U.R.A. 200), Faculté des Sciences Pharmaceutiques et Biologiques, Paris.

出版信息

Pharm Acta Helv. 1991;66(11):307-10.

PMID:1758890

Abstract

Carbamazepine dihydrate (CBZ.2H2O) crystallizes in the orthorhombic system, space group Cmca or C2ca. The unit-cell constants are: a = 19.834(7), b = 4.945(1), c = 28.826(9) A. M = 272.27, V = 2827(2) A3, Z = 8, D = 1.280 g.cm-3. Indexed X-ray powerder diffraction pattern is given. Dehydration process was studied by means of thermogravimetry and differential thermal analysis: the enthalpy of dehydration was found at 51 kJ per H2O mole. Thermal dehydration leads to an (anhydrous) gamma-form of CBZ when processed in dry atmosphere. The presence of water vapour induces the formation of the beta-form of CBZ as well as the grinding of CBZ.2H2O at room temperature.

摘要

二水合卡马西平（CBZ·2H₂O）结晶于正交晶系，空间群为Cmca或C2ca。晶胞常数为：a = 19.834(7)，b = 4.945(1)，c = 28.826(9) Å。M = 272.27，V = 2827(2) Å³，Z = 8，D = 1.280 g·cm⁻³。给出了X射线粉末衍射图谱的指标化结果。通过热重分析和差示热分析研究了脱水过程：发现每摩尔H₂O的脱水焓为51 kJ。在干燥气氛中处理时，热脱水会导致形成（无水）γ型CBZ。水蒸气的存在会诱导形成β型CBZ，以及在室温下研磨CBZ·2H₂O。