Gradman Josefine, Wolthers Ole D
Children's Clinic Randers, Randers, Denmark.
Acta Paediatr. 2007 Aug;96(8):1233-7. doi: 10.1111/j.1651-2227.2007.00363.x. Epub 2007 Jun 21.
Treatment with topical glucocorticoids in children with atopic eczema may be associated with systemic adverse effects, such as suppression of growth.
To asses if treatment with topical mometasone furoate 0.1% or topical tacrolimus 0.1% affects short-term growth in children with atopic eczema. Primary outcome measures were lower leg growth rates measured by knemometry.
Twenty 5- to 12-year-old prepubertal children with atopic eczema were included in a randomised, investigator-blind crossover study with five periods: two treatment periods, a run in, a wash out and a run out. All periods were of 2-week duration. The subjects applied mometasone furoate ointment 0.1% once daily during one treatment period and tacrolimus ointment 0.1% twice daily during the other treatment period.
As compared to run in mean lower leg growth rate during mometasone furoate and tacrolimus treatment was reduced by 0.09 and 0.06 mm/week, respectively, (F = 1.12, p = 0.35). Consistently, no statistically significant effects on urine levels of eosinophil protein X and crossed-linked N-telopeptides were detected.
Treatment with mometasone furoate or tacrolimus does not affect short-term growth in children with mild to moderate atopic eczema.
外用糖皮质激素治疗特应性皮炎患儿可能会产生全身不良反应，如生长抑制。
评估0.1%糠酸莫米松或0.1%他克莫司外用治疗对特应性皮炎患儿短期生长的影响。主要结局指标是通过小腿测量法测量的小腿生长速率。
20名5至12岁青春期前的特应性皮炎患儿纳入一项随机、研究者盲法交叉研究，该研究有五个阶段：两个治疗阶段、一个导入期、一个洗脱期和一个恢复期。所有阶段均为期2周。受试者在一个治疗阶段每天外用一次0.1%糠酸莫米松软膏，在另一个治疗阶段每天外用两次0.1%他克莫司软膏。
与导入期相比，糠酸莫米松和他克莫司治疗期间小腿平均生长速率分别降低了0.09和0.06毫米/周（F = 1.12，p = 0.35）。同样，未检测到对嗜酸性粒细胞蛋白X和交联N-端肽尿液水平有统计学意义的影响。
糠酸莫米松或他克莫司治疗不影响轻至中度特应性皮炎患儿的短期生长。
