Dernis Emmanuelle, Lavie Frédéric, Pavy Stéphan, Wendling Daniel, Flipo René-Marc, Saraux Alain, Cantagrel Alain, Claudepierrre Pascal, Goupille Philippe, Le Loët Xavier, Maillefert Jean Francis, Mariette Xavier, Schaeverbeke Thierry, Tebib Jacques, Combe Bernard
Service de Rhumatologie, CH Le Mans, Le Mans, France.
Joint Bone Spine. 2007 Jul;74(4):330-7. doi: 10.1016/j.jbspin.2007.04.002. Epub 2007 May 30.
To develop French recommendations about the clinical and laboratory follow-up of patients with axial ankylosing spondylitis (AS) seen in everyday practice.
The recommendations were developed based on evidence from the literature and on expert opinion. A Delphi consensus procedure was used by a scientific committee to select five focal points, about which evidence was obtained by searching Medline and the databases maintained by the French Society for Rheumatology, European League against Rheumatism, and American College of Rheumatology. The results of the literature review were used by a panel of experienced rheumatologists to draft and to validate the recommendations, using expert opinion if needed to supplement gaps in published knowledge. For each recommendation, the level of evidence and the level of agreement among the experts were specified.
The three focal points selected using the Delphi procedure dealt with choosing the best clinical and laboratory parameters for monitoring patients with AS; whether follow-up benefits from the use of composite indices (e.g., the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], the BAS Functional Index [BASFI] and the BAS Metrology Index [BASMI]); and the clinical and laboratory parameters that predict functional or structural outcomes in patients with AS. The literature search retrieved 1510 relevant articles based on titles and abstracts, of which 322 were selected for in-depth review. Five recommendations about the clinical and laboratory follow-up of patients with AS were developed then validated by having all panel participants vote during a final meeting.
Recommendations about the clinical and laboratory follow-up of patients with AS were developed. They can be expected to improve clinical practice uniformity and, in the longer term, to optimize the management of patients with AS.
制定关于日常临床中轴性强直性脊柱炎（AS）患者临床及实验室随访的法国专家建议。
这些建议基于文献证据和专家意见制定。一个科学委员会采用德尔菲共识程序选择了五个重点问题，通过检索Medline以及法国风湿病学会、欧洲抗风湿病联盟和美国风湿病学会维护的数据库获取相关证据。一组经验丰富的风湿病专家利用文献综述结果起草并验证这些建议，必要时运用专家意见补充已发表知识中的空白。对于每条建议，都明确了证据水平和专家间的一致程度。
通过德尔菲程序选出的三个重点问题涉及为AS患者监测选择最佳临床及实验室参数；使用综合指标（如巴斯强直性脊柱炎疾病活动指数[BASDAI]、巴斯功能指数[BASFI]和巴斯计量指数[BASMI]）进行随访是否有益；以及预测AS患者功能或结构转归的临床及实验室参数。基于标题和摘要的文献检索共找到1510篇相关文章，其中322篇被选作深入综述。随后制定了五条关于AS患者临床及实验室随访的建议，并在最后一次会议上让所有参与小组的成员投票进行了验证。
制定了关于AS患者临床及实验室随访的建议。预计这些建议可提高临床实践的一致性，并从长远来看优化AS患者的管理。
