[2-甲基丙烯酰氧乙基磷酰胆碱聚合物膜的研究进展与应用前景]

[The research advancement and the application foreground of 2-methacryloyloxyethyl phosphorylcholine polymer membranes].

作者信息

Wang Changhe, Wang Zhaoyang, Cao Lin, Jiang Ping, Guo Cong

机构信息

College of Life Science, Sichuan University, Chengdu 610064, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Apr;24(2):470-3.

DOI:

PMID:17591285

Abstract

2-methacryloyloxyethyl phosphorylcholine (MPC) polymer membranes are synthesized as biomaterials of the biomembrane structure. The MPC polymer membranes have excellent biocompatibility and blood compatibility, they can effectively reduce protein adsorption and denaturation and inhibit cell adhesion even when the polymer membranes are in contact with whole blood in the absence of any anticoagulants. So, the MPC polymer membranes are widely used in blood purification, artificial organs, membrane oxygenator, and other field of biomedicine. The paper mainly expounds the research advancement and the application prospect of MPC polymer membranes.

摘要

2-甲基丙烯酰氧乙基磷酰胆碱（MPC）聚合物膜作为具有生物膜结构的生物材料被合成。MPC聚合物膜具有优异的生物相容性和血液相容性，即使在没有任何抗凝剂的情况下，当聚合物膜与全血接触时，它们也能有效减少蛋白质吸附和变性，并抑制细胞黏附。因此，MPC聚合物膜广泛应用于血液净化、人工器官、膜式氧合器及其他生物医药领域。本文主要阐述了MPC聚合物膜的研究进展及应用前景。