Becker Carolyn
Toni Stabile Osteoporosis Center, Columbia University, New York, NY 10032, USA.
Clin Cornerstone. 2006;8(1):19-27. doi: 10.1016/s1098-3597(06)80062-1.
Osteoporosis is a complex skeletal disorder in which compromised bone strength increases the risk of fragility fractures. Recent scientific advances in bone biology and immunology have greatly expanded our insights into the pathogenesis of osteoporosis. For those with osteoporotic fractures, however, the physical and psychological effects remain severe. Primary care physicians need to understand the basic mechanisms of bone physiology and pathophysiology in order to both prevent and treat this devastating disorder.
骨质疏松症是一种复杂的骨骼疾病，其中骨强度受损会增加脆性骨折的风险。近年来，骨生物学和免疫学的科学进展极大地拓展了我们对骨质疏松症发病机制的认识。然而，对于骨质疏松性骨折患者来说，其身体和心理影响仍然很严重。基层医疗医生需要了解骨骼生理和病理生理的基本机制，以便预防和治疗这种破坏性疾病。
