Orditura M, Martinelli E, Galizia G, Vitiello F, Fasano M, Muto P, Ciardiello F, De Vita F
Department of Medical Oncology, F. Magrassi & A. Lanzara, Second University of Naples School of Medicine, Naple, Italy.
Ann Oncol. 2007 Jun;18 Suppl 6:vi133-5. doi: 10.1093/annonc/mdm242.
Historically, radiotherapy has been occasionally used in the treatment of gastric cancer. More recently, the results of INT-0116 trial have shown an improvement of disease-free and overall survival by chemoradiation with a significant impact on the management of this tumor. Based on these data, there has been an increasing interest in radiotherapy and its association with chemotherapy for patients with locoregional disease as a part of an adjuvant treatment after surgery in high-risk patients. However, many questions remain to evaluate; first of all the toxicity of this approach and its efficacy after adequate surgery.
从历史上看，放射疗法偶尔用于治疗胃癌。最近，INT-0116试验的结果表明，放化疗可改善无病生存期和总生存期，对这种肿瘤的治疗产生了重大影响。基于这些数据，对于局部区域疾病患者，作为高危患者术后辅助治疗的一部分，放射疗法及其与化疗的联合应用越来越受到关注。然而，仍有许多问题有待评估；首先是这种治疗方法的毒性及其在充分手术后的疗效。
