Muhonen M G, Godersky J C, VanGilder J C
Division of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City 52242.
Surg Neurol. 1991 Dec;36(6):470-5. doi: 10.1016/0090-3019(91)90163-4.
An uncommonly recognized complication of neurofibromatosis (NF) is an angiopathy of the intracranial and extracranial arteries. Most of the previously reported cases have presented as an occlusive process similar to Moyamoya disease. We present our experience over the past 3 years involving three patients with five cerebral aneurysms and associated NF. Four of the aneurysms were intracranial, two being fusiform in nature. Treatment was surgical occlusion and included Selverstone clamping, balloon occlusion, and direct clipping. There appears to be an association between the development of cerebral artery aneurysms and NF, but the pathophysiology of these vascular changes is not fully understood.
神经纤维瘤病（NF）一种鲜为人知的并发症是颅内和颅外动脉的血管病变。先前报道的大多数病例表现为类似于烟雾病的闭塞性病变。我们介绍过去3年中涉及3例患者共5个脑动脉瘤及相关NF的经验。其中4个动脉瘤位于颅内，2个为梭形。治疗方法为手术闭塞，包括塞尔弗斯通夹闭术、球囊闭塞术和直接夹闭术。脑动脉瘤的发生与NF之间似乎存在关联，但这些血管变化的病理生理学尚未完全明了。
