[遗传性高胆固醇血症患者低密度脂蛋白去除术中免疫球蛋白和循环免疫复合物浓度的动态变化]
[The dynamics of the concentrations of immunoglobulins and circulating immune complexes during low-density lipoprotein apheresis in patients with hereditary hypercholesterolemia].
作者信息
Bokchubaev E T, Konovalov G A, Nasonov E L, Kukharchuk V V
出版信息
Ter Arkh. 1991;63(9):62-4.
Sessions of-low density lipoproteins (LDL) apheresis using sorbents with mono- and polyclonal antibodies possessing the most selective and specific effect with respect to LDL provoked a less marked decrease of the concentrations of immunoglobulins and circulating immune complexes. This attests to their high selectivity and specificity. Sorbents with dextran sulfate and heparin sepharose exerted a more evident influence on the concentrations of these serum components. However, that was not accompanied by any clinical manifestations of immune deficiency. The use of plasmapheresis brought about a more pronounced lowering of the concentrations of the serum components under study.
使用对低密度脂蛋白（LDL）具有最具选择性和特异性作用的单克隆和多克隆抗体吸附剂进行低密度脂蛋白（LDL）血液成分分离术，引起免疫球蛋白和循环免疫复合物浓度的下降不太明显。这证明了它们的高选择性和特异性。硫酸葡聚糖和肝素琼脂糖吸附剂对这些血清成分的浓度有更明显的影响。然而，这并未伴随任何免疫缺陷的临床表现。血浆置换术的使用使所研究的血清成分浓度有更明显的降低。
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