Troxler R G, Park M K, Miller M A, Karnavas B A, Lee D H
Department of Pediatrics, University of Texas Health Science Center, San Antonio 78285.
Tex Med. 1991 Nov;87(11):75-9.
Plasma levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were obtained in 110 senior high school students who were predominantly Hispanic. Results were compared with family history of premature coronary heart disease or hypercholesterolemia. The level of high-density lipoprotein cholesterol was significantly lower in Hispanic adolescents than in non-Hispanics (P less than 0.05). A positive family history was found in 22% of the subjects. Only 25% of the students with high levels of total cholesterol had a positive family history. The positive predictive value of family history for a high level of total cholesterol was only 38%. These results suggest that adolescents should be screened for hypercholesterolemia regardless of a positive family history.
对110名以西班牙裔为主的高中生进行了总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的血浆水平检测。将结果与早发性冠心病或高胆固醇血症家族史进行比较。西班牙裔青少年的高密度脂蛋白胆固醇水平显著低于非西班牙裔青少年（P小于0.05）。22%的受试者有阳性家族史。总胆固醇水平高的学生中只有25%有阳性家族史。家族史对总胆固醇水平高的阳性预测值仅为38%。这些结果表明，无论家族史是否为阳性，青少年都应接受高胆固醇血症筛查。
