Rho激酶抑制剂法舒地尔对易卒中型自发性高血压大鼠视网膜小动脉的血管舒张作用。
Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats.
作者信息
Okamura Nami, Saito Maki, Mori Asami, Sakamoto Kenji, Kametaka Sokichi, Nakahara Tsutomu, Ishii Kunio
机构信息
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, Tokyo, Japan.
出版信息
J Ocul Pharmacol Ther. 2007 Jun;23(3):207-12. doi: 10.1089/jop.2006.128.
PURPOSE
The aim of this study was to examine the vasodilator effect of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats (SHRSPs) and in age-matched normotensive Wistar-Kyoto rats (WKYs).
METHODS
Rats (12-14 weeks-old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneal). Fundus images were captured with a digital camera that was equipped with a special objective lens. The vasodilator responses of retinal arterioles were assessed by measuring changes in the diameters of the vessels.
RESULTS
The baseline diameter of the retinal arteriole was significantly smaller in SHRSPs than in WKYs. Fasudil (50-200 microg/kg/min, intravenous) dose-dependently increased the diameter of the retinal arteriole and decreased the systemic blood pressure in both groups. The vasodilator effect of fasudil on the retinal arteriole in SHRSPs was greater than in WKYs.
CONCLUSIONS
These results suggest that fasudil has beneficial effects on retinal vascular complications associated with chronic hypertension.
目的
本研究旨在探讨Rho激酶抑制剂法舒地尔对易卒中型自发性高血压大鼠（SHRSPs）和年龄匹配的正常血压Wistar - Kyoto大鼠（WKYs）视网膜小动脉的血管舒张作用。
方法
用硫喷妥钠（120 mg/kg，腹腔注射）麻醉12 - 14周龄大鼠。用配备特殊物镜的数码相机拍摄眼底图像。通过测量血管直径的变化来评估视网膜小动脉的血管舒张反应。
结果
SHRSPs视网膜小动脉的基线直径显著小于WKYs。法舒地尔（50 - 200 μg/kg/min，静脉注射）在两组中均剂量依赖性地增加视网膜小动脉直径并降低全身血压。法舒地尔对SHRSPs视网膜小动脉的血管舒张作用大于WKYs。
结论
这些结果表明法舒地尔对与慢性高血压相关的视网膜血管并发症具有有益作用。
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