Fentiman Ian S
Guy's King's and St. Thomas' School of Medicine, London, United Kingdom.
Breast J. 2007 Jul-Aug;13(4):406-9. doi: 10.1111/j.1524-4741.2007.00449.x.
An increasing proportion of patients with breast cancer are aged above 70 at the time of diagnosis and yet this particular age group has been underserved in terms of clinical research. Good communication between a doctor and a patient implies giving the advice and treatment most appropriate to that particular individual's needs, based upon their health and the tumor characteristics in the framework of their experience and belief system. Doctors need to be able to pick up both verbal and nonverbal cues and whenever possible to place the needs of the patient rather than her relatives as paramount. Consultations may be blighted at the onset by delays, unsympathetic staff, and patronizing doctors. Many older patients will wish to avoid mastectomy and for those with hormonally sensitive tumors wide excision and tamoxifen without axillary clearance or breast irradiation may provide a safe option. Undertreatment of those with hormonally insensitive cancer may lead to an increased risk of recurrence and premature death from breast cancer. Although there is an increasing realization of the need for clinical studies in older patients this group are grossly under-represented in trial portfolios.
乳腺癌患者中,诊断时年龄在70岁以上的比例日益增加,但就临床研究而言,这一特定年龄组一直未得到充分关注。医生与患者之间良好的沟通意味着,基于患者的健康状况和肿瘤特征,在医生的经验和信念体系框架内,提供最适合该特定个体需求的建议和治疗方案。医生需要能够捕捉到言语和非言语线索,并尽可能将患者而非其亲属的需求置于首位。会诊一开始可能就会因延误、缺乏同情心的工作人员和盛气凌人的医生而受到影响。许多老年患者希望避免乳房切除术,对于那些激素敏感型肿瘤患者,广泛切除加他莫昔芬治疗,不进行腋窝清扫或乳房放疗可能是一种安全的选择。对激素不敏感型癌症患者治疗不足可能会增加复发风险和因乳腺癌过早死亡的风险。尽管人们越来越意识到老年患者需要进行临床研究,但在试验项目中,这一年龄组的代表性严重不足。