Miwa H, Nakajima K, Yamaguchi K, Fujimoto K, Veldhuyzen VAN Zanten S J O, Kinoshita Y, Adachi K, Kusunoki H, Haruma K
Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Aliment Pharmacol Ther. 2007 Jul 15;26(2):257-64. doi: 10.1111/j.1365-2036.2007.03367.x.
The relationship between acid and dyspeptic symptoms has not been fully understood.
To investigate the type and severity of dyspeptic symptoms induced by direct acid infusion into the stomach of Japanese healthy subjects.
This was a multi-centre, cross-over, randomized, double-blind study in 27 healthy subjects (mean age 27). Each fasted subject received two tests with 150 mL of 0.1 mol/L hydrochloric acid infusion (15 mL/min for 10 min) and the same volume of pure water infusion. The type and severity of symptoms were assessed by a 10 cm visual analogue scale administered every 2 min up to 30 min.
Various symptoms were reported after both acid and water infusions. Most of the symptoms were more severe after acid infusion compared with water infusion (acid vs. water: discomfort 1.8 +/- 0.4 vs. 0.5 +/- 0.1, pain 0.6 +/- 0.3 vs. 0.1 +/- 0.1, reflux 1.0 +/- 0.3 vs. 0.3 +/- 0.1 and satiety 1.1 +/- 0.4 vs. 0.2 +/- 0.1). The area under curve for dysmotility like symptoms (heavy feeling in the stomach, bloating, nausea or feeling sick, and belching) was significantly higher in acid infusion, and symptoms continued after infusion of the acid.
Acid induced into stomach induced dysmotility-like predominant dyspeptic symptoms in Japanese healthy control subjects, demonstrating the possible importance of acid in symptom generation.
酸与消化不良症状之间的关系尚未完全明确。
研究直接向日本健康受试者胃内输注酸所诱发的消化不良症状的类型及严重程度。
这是一项针对27名健康受试者（平均年龄27岁）的多中心、交叉、随机、双盲研究。每位空腹受试者接受两次测试，分别输注150毫升0.1摩尔/升盐酸（以15毫升/分钟的速度输注10分钟）和相同体积的纯水。每2分钟使用10厘米视觉模拟量表评估症状类型及严重程度，直至30分钟。
输注酸和水后均报告了各种症状。与输注水相比，输注酸后大多数症状更为严重（酸与水相比：不适感1.8±0.4对0.5±0.1，疼痛0.6±0.3对0.1±0.1，反流1.0±0.3对0.3±0.1，饱腹感1.1±0.4对0.2±0.1）。酸输注后，类似动力障碍症状（胃部沉重感、腹胀、恶心或不适、嗳气）的曲线下面积显著更高，且输注酸后症状仍持续。
向胃内输注酸可在日本健康对照受试者中诱发以动力障碍为主的消化不良症状，表明酸在症状产生中可能具有重要作用。
