功能性消化不良患者与健康者在摄入等热量流质饮食后胃容积的个体间及个体内变异性。
Intersubject and intrasubject variability of gastric volumes in response to isocaloric liquid meals in functional dyspepsia and health.
作者信息
Fruehauf H, Goetze O, Steingoetter A, Kwiatek M, Boesiger P, Thumshirn M, Schwizer W, Fried M
机构信息
Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
出版信息
Neurogastroenterol Motil. 2007 Jul;19(7):553-61. doi: 10.1111/j.1365-2982.2007.00904.x.
Gastric emptying (GE) has a considerable variability, but data on reproducibility of gastric volume measurements are sparse. We aimed to study the reproducibility of postprandial gastric volume responses and GE using magnetic resonance imaging (MRI) in healthy controls (HC) and patients with functional dyspepsia (FD). Eight HC and eight FD patients underwent a MRI study on two occasions. MR images were acquired in seated position before and up to 120 min after liquid meal administration (200 mL, 300 kcal). Fasting (V0), initial postprandial stomach volumes (V1), volume changes (V1 - V0) and meal emptying half-times (T 1/2) were determined. Intersubject and intrasubject coefficients of variation (CV(inter), CV(intra)) and Pearson's correlation coefficients (r) were calculated. T 1/2 on both occasions were (mean +/- SD) 113 +/- 28 and 121 +/- 30 min in HC (ns) and 127 +/- 31 and 128 +/- 37 min in FD (ns), respectively. In HC, CV(inter), CV(intra), r were 31%, 23%, 0.49 for V0; 13%, 7%, 0.68 for V1; 10%, 4%, 0.71 for V1 - V0 and 25%, 7%, 0.90 for T 1/2. In FD these parameters were for V0: 42%, 41%, -0.06; for V1: 18%, 10%, 0.40; for V1 - V0: 20%, 14%, 0.74 and for T 1/2: 26%, 10%, 0.84. The stomach accommodates to a given meal volume, resulting in similar and reproducible postprandial volumes within- and between-subjects. MRI provides reproducible measurements of gastric volume responses in health and disease.
胃排空（GE）具有相当大的变异性，但关于胃容量测量可重复性的数据却很稀少。我们旨在研究健康对照者（HC）和功能性消化不良（FD）患者中，使用磁共振成像（MRI）测量餐后胃容量反应和胃排空的可重复性。8名HC和8名FD患者分两次接受了MRI研究。在坐位下，于给予流食（200 mL，300千卡）前及之后长达120分钟采集MR图像。测定空腹时（V0）、餐后初始胃容量（V1）、容量变化（V1 - V0）和食物排空半衰期（T1/2）。计算受试者间和受试者内变异系数（CV(inter)，CV(intra)）以及皮尔逊相关系数（r）。两次测量时，HC的T1/2分别为（均值±标准差）113±28分钟和121±30分钟（无显著差异），FD的T1/2分别为127±31分钟和128±37分钟（无显著差异）。在HC中，V0的CV(inter)、CV(intra)、r分别为31%、23%、0.49；V1的分别为13%、7%、0.68；V1 - V0的分别为10%、4%、0.71；T1/2的分别为25%、7%、0.90。在FD中，这些参数对于V0分别为：42%、41%、 -0.06；对于V1分别为：18%、10%、0.40；对于V1 - V0分别为：20%、14%、0.74；对于T1/2分别为：26%、10%、0.84。胃能够适应给定的进餐量，从而在受试者内和受试者间产生相似且可重复的餐后容量。MRI能够在健康和疾病状态下提供可重复的胃容量反应测量。
Zotero 插件