Cuestas Eduardo, Caceres Alfredo, Palacio Santiago
Servicio de Pediatría y Neonatología, Hospital Privado, Córdoba.
Medicina (B Aires). 2007;67(2):177-82.
Animal models of injury and repair in developing brain. Brain injury is a major contributor to neonatal morbidity and mortality, a considerable group of these children will develop long term neurological sequels. Despite the great clinical and social significance and the advances in neonatal medicine, no therapy yet does exist that prevent or decrease detrimental effects in cases of neonatal brain injury. Our objective was to review recent research in relation to the hypothesis for repair mechanism in the developing brain, based in animal models that show developmental compensatory mechanisms that promote neural and functional plasticity. A better understanding of these adaptive mechanisms will help clinicians to apply knowledge derived from animals to human clinical situations.
发育中大脑损伤与修复的动物模型。脑损伤是新生儿发病和死亡的主要原因，相当一部分此类儿童会出现长期神经后遗症。尽管脑损伤具有重大的临床和社会意义，且新生儿医学也取得了进展，但目前尚无预防或减轻新生儿脑损伤有害影响的治疗方法。我们的目标是基于动物模型来综述与发育中大脑修复机制假说相关的最新研究，这些动物模型显示出促进神经和功能可塑性的发育补偿机制。更好地理解这些适应性机制将有助于临床医生将从动物研究中获得的知识应用于人类临床情况。
