Erlacher L, Gisslinger H, Chott A
II. Medizinische Universitätsklinik, Wien.
Wien Klin Wochenschr. 1991;103(19):588-90.
Long-term treatment with recombinant interferon alpha (IFN) leading to complete remission in a patient with hairy cell leukaemia is presented. Four months after the beginning of treatment with IFN, the parameters of the peripheral blood had normalized. In spite of a continuous dose reduction (to a dose of 1 Mio. U/week) remission could be maintained during the six years of treatment. Two years after the start of treatment with IFN, a metastasizing carcinoma of the prostate was diagnosed, leading to death after four years. With regard to the hairy cell leukaemia, the patient was free of symptoms and the obduction confirmed the complete remission: the histological examination of bone marrow, spleen, liver and lymph nodes showed no more signs of hairy cell leukaemia. This case report shows that long-term treatment with IFN in some cases is effective to induce and to maintain complete remission in hairy cell leukaemia.
本文介绍了一名毛细胞白血病患者接受重组干扰素α（IFN）长期治疗后实现完全缓解的病例。IFN治疗开始四个月后，外周血参数恢复正常。尽管持续降低剂量（降至100万单位/周），在六年的治疗期间仍维持了缓解状态。IFN治疗开始两年后，诊断出前列腺转移性癌，四年后导致患者死亡。关于毛细胞白血病，患者无症状，尸检证实完全缓解：骨髓、脾脏、肝脏和淋巴结的组织学检查未显示毛细胞白血病的迹象。本病例报告表明，IFN长期治疗在某些情况下对诱导和维持毛细胞白血病的完全缓解有效。
