Gupta R K, Relyveld E H
National Institutes of Health, Bethesda, MD 20892.
Vaccine. 1991 Oct;9(10):699-702. doi: 10.1016/0264-410x(91)90283-c.
Reactions to adsorbed diphtheria-pertussis-tetanus (DPT) vaccine have mostly been attributed to the pertussis organisms or pertussis components in the vaccine. Nevertheless reactions may also be due to other factors such as sensitization induced by aluminium adjuvants and impurities present in crude toxoids that cannot be removed by purification of toxoids after formalinization. Aluminium compounds such as aluminium phosphate and aluminium hydroxide are the most commonly used adjuvants with vaccines for human use. Due to the increasing concern about the toxicity of aluminium, other adjuvants like calcium phosphate may be evaluated as an alternative to aluminium adjuvants. To minimize reactions after immunization with DPT vaccine due to impurities in the toxoids, the use of toxoided purified toxins is suggested.
对白喉-百日咳-破伤风（DPT）吸附疫苗的反应大多归因于疫苗中的百日咳杆菌或百日咳成分。然而，反应也可能归因于其他因素，如铝佐剂引起的致敏作用以及粗制类毒素中存在的杂质，这些杂质在类毒素经甲醛处理后纯化时无法去除。诸如磷酸铝和氢氧化铝之类的铝化合物是人类疫苗中最常用的佐剂。由于对铝毒性的日益关注，其他佐剂如磷酸钙可能会被评估作为铝佐剂的替代品。为了尽量减少因类毒素中的杂质而在接种DPT疫苗后出现的反应，建议使用类毒素纯化毒素。
