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3-磷酸甘油醛脱氢酶是胰岛素模拟物去甲基曲霉醌B1的细胞靶点。

Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.

作者信息

Kim Hyunsoo, Deng Liu, Xiong Xin, Hunter William D, Long Melissa C, Pirrung Michael C

出版信息

J Med Chem. 2007 Jul 26;50(15):3423-6. doi: 10.1021/jm070437i. Epub 2007 Jun 27.

DOI:10.1021/jm070437i
PMID:17595071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2556249/
Abstract

This study was undertaken to identify cellular proteins that bind an orally active natural product insulin mimic. Phage display cloning was used with a biotinylated derivative of this molecule as bait. Among the proteins identified was glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which has recently been shown to affect insulin receptor signaling. Binding data support a role for human GAPDH as another target of the insulin mimic, which could explain its action as a selective insulin receptor modulator.

摘要

本研究旨在鉴定与一种口服活性天然产物胰岛素模拟物结合的细胞蛋白。以该分子的生物素化衍生物作为诱饵进行噬菌体展示克隆。鉴定出的蛋白中有甘油醛-3-磷酸脱氢酶（GAPDH），最近研究表明它会影响胰岛素受体信号传导。结合数据支持人GAPDH作为胰岛素模拟物的另一个靶点发挥作用，这可以解释其作为选择性胰岛素受体调节剂的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/cc23baef87ff/nihms62538f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/c713740e5abf/nihms62538f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/fbc106139101/nihms62538f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/732a835a96ee/nihms62538f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/cc23baef87ff/nihms62538f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/c713740e5abf/nihms62538f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/fbc106139101/nihms62538f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/732a835a96ee/nihms62538f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f8/2556249/cc23baef87ff/nihms62538f4.jpg

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