Meskhi I A, Sikharulidze E N, Natmeladze K V
Georgian Med News. 2007 May(146):11-3.
This study was designed to clarify the efficacy of combination of thyroid hormone (euthyrox) therapy and percutaneous ethanol injection (PEI) in benign nodular thyroid diseases. 55 patients with benign nodular goiter after the first PEI session during the whole study period (from 3 till 12 months after PEI) daily received euthyrox in a dosage - 50 mkg. 48 women and 7 men with thyroid nodules of the various sizes, structures and echogenecity have been included in the study group. The control group consisted of 32 patients: 29 women and 3 men in the same age range as in the study group. In both groups PEI procedure was performed but in the control group no thyroid hormone was added. In patients who were receiving 50 mkg daily after 3 months of PEI progressive reduction of the nodule sizes was registered, the volume of a thyroid gland has decreased and approached to normal parameters (15,79+/-1,21 ml), and in 6-2 months the normal volume of the thyroid gland was registered. Thus, combination of thyroid hormone therapy and percutaneous ethanol injection (PEI) in treatment of patients with benign nodular goiter normalizes the size of a thyroid gland. Euthyrox is the additional factor causing reduction of thyroid nodules and constraining occurrence of new nodules in a thyroid gland.
本研究旨在阐明甲状腺激素（优甲乐）疗法与经皮乙醇注射（PEI）联合应用于良性结节性甲状腺疾病的疗效。在整个研究期间（PEI后3至12个月），55例首次接受PEI治疗的良性结节性甲状腺肿患者每日服用剂量为50微克的优甲乐。研究组纳入了48名女性和7名男性，他们患有各种大小、结构和回声性的甲状腺结节。对照组由32名患者组成：29名女性和3名男性，年龄范围与研究组相同。两组均进行了PEI操作，但对照组未加用甲状腺激素。在PEI 3个月后每天接受50微克治疗的患者中，结节大小逐渐减小，甲状腺体积减小并接近正常参数（15.79±1.21毫升），6至2个月时甲状腺体积恢复正常。因此，甲状腺激素疗法与经皮乙醇注射（PEI）联合应用于治疗良性结节性甲状腺肿患者可使甲状腺大小恢复正常。优甲乐是导致甲状腺结节缩小并抑制甲状腺内新结节出现的额外因素。
