Ohmi G, Kinoshita H, Kinoshita S
Department of Ophthalmology, Osaka University Medical School, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Nov;95(11):1099-104.
Accommodative and pupillary responses, refractive change, and visual acuity after 30 microliters instillation of cyclopentolate hydrochloride of various concentrations (0.00625-0.1%) in 6 young normal males (27.0 +/- 0.6 yrs) were investigated. Both accommodative and pupillary responses were measured by an infrared optometer, at pre-instillation and 1, 3, 6, 9 and 24 hours post-instillation. No significant effects were induced by concentrations of cyclopentolate hydrochloride 0.0125% or less. Reduced amplitude of accommodation and enlarged pupil were, however, observed by 0.025% and 0.05% of cyclopentolate hydrochloride from 1 through 9 hours post-instillation. Miotic response in accommodation was also reduced from 1-6 hours at the same concentrations. A concentration of 0.1% cyclopentolate hydrochloride showed both reduction of accommodation amplitude and enlarged pupil for 24 hours after instillation. However, neither refraction nor visual acuity was affected by any concentration of cyclopentolate hydrochloride. The results suggest that cyclopentolate hydrochloride at concentrations up to 0.05% applied before sleep would not be accompanied by inhibitory effects on accommodation during the day.
研究了6名年轻正常男性（27.0±0.6岁）滴入30微升不同浓度（0.00625 - 0.1%）盐酸环喷托酯后的调节和瞳孔反应、屈光变化及视力。调节和瞳孔反应通过红外验光仪在滴药前及滴药后1、3、6、9和24小时进行测量。0.0125%及以下浓度的盐酸环喷托酯未产生显著影响。然而，滴入0.025%和0.05%盐酸环喷托酯后1至9小时，观察到调节幅度降低和瞳孔扩大。相同浓度下，调节中的瞳孔缩小反应在1至6小时也有所降低。0.1%盐酸环喷托酯滴入后24小时均表现出调节幅度降低和瞳孔扩大。然而，任何浓度的盐酸环喷托酯均未影响屈光和视力。结果表明，睡前使用浓度高达0.05%的盐酸环喷托酯不会在白天对调节产生抑制作用。
