Kaneko Osamu
Department of Molecular Parasitology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
Parasitol Int. 2007 Dec;56(4):255-62. doi: 10.1016/j.parint.2007.05.003. Epub 2007 May 29.
Malaria is a dangerous infectious disease caused by obligate intracellular protozoan Plasmodium parasites. In the vertebrate host, erythrocyte recognition and establishment of a nascent parasitophorous vacuole are essential processes, and are largely achieved using molecules located in the microorganelles of the invasive-stage parasites. Recent proteome analyses of the phylogenetically related Toxoplasma parasite have provided protein catalogs for these microorganelles, which can now be used to identify orthologous proteins in the Plasmodium genome. Of importance is the formation of a complex between the proteins secreted from the rhoptry neck portion (RONs) and micronemes (AMA1), which localize at the moving junction during parasite invagination into the host cell. In this article I review the largely unexplored paradigm of the malaria merozoite rhoptry, focusing on the high molecular weight rhoptry protein complex (the RhopH complex), and speculate on its grammar during invasion.
疟疾是一种由专性细胞内原生动物疟原虫寄生虫引起的危险传染病。在脊椎动物宿主中，红细胞识别和新生寄生泡的形成是必不可少的过程，并且很大程度上是通过侵入期寄生虫微细胞器中的分子来实现的。最近对系统发育相关的弓形虫寄生虫进行的蛋白质组分析为这些微细胞器提供了蛋白质目录，现在可用于识别疟原虫基因组中的直系同源蛋白质。重要的是，来自棒状体颈部部分（RONs）和微线体（AMA1）分泌的蛋白质之间形成复合物，这些蛋白质在寄生虫侵入宿主细胞期间定位于移动连接点。在本文中，我回顾了疟疾裂殖子棒状体这一基本未被探索的范例，重点关注高分子量棒状体蛋白复合物（RhopH复合物），并推测其在入侵过程中的作用机制。
