基质蛋白1：对甲型H5N1流感病毒不同毒株的计算机模拟比较研究
Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus.
作者信息
Anwar Tamanna, Lal Sunil K, Khan Asad U
机构信息
Distributed Information Sub-centre, Aligarh Muslim University, Aligarh 202002, India.
出版信息
Bioinformation. 2006 Nov 22;1(7):253-6. doi: 10.6026/97320630001253.
Abstract
The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.
摘要
流感病毒作为全球感染源的重要性已得到充分认可。流感病毒的特定突变和进化难以预测。我们使用生物信息学开发的预测工具，研究了甲型H5N1流感病毒基质蛋白1（M1）的特定突变及其相关特性。我们注意到并记录了突变位点处疏水性、极性和二级结构的变化，以深入了解其感染机制。
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本文引用的文献
1
MAP MUTATION: a program for analyzing mutations in protein sequences.
Bioinformation. 2006 Feb 20;1(3):92-3. doi: 10.6026/97320630001092.
2
3
Human infection by avian influenza A H5N1.
Hong Kong Med J. 2005 Jun;11(3):189-99.
4
A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence.
Virology. 2005 Jun 5;336(2):318-26. doi: 10.1016/j.virol.2005.03.028.
5
Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.
J Virol. 2005 Feb;79(3):1918-23. doi: 10.1128/JVI.79.3.1918-1923.2005.
6
Re-emergence of fatal human influenza A subtype H5N1 disease.
Lancet. 2004 Feb 21;363(9409):617-9. doi: 10.1016/S0140-6736(04)15595-5.
7
Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997.
Clin Infect Dis. 2002 May 1;34 Suppl 2:S58-64. doi: 10.1086/338820.
8
Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export.
Virology. 2001 Sep 1;287(2):405-16. doi: 10.1006/viro.2001.1067.
9
In vitro dissection of the membrane and RNP binding activities of influenza virus M1 protein.
Virology. 2001 Mar 1;281(1):102-8. doi: 10.1006/viro.2000.0804.
10
Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes.
J Virol. 2000 Aug;74(15):6800-7. doi: 10.1128/jvi.74.15.6800-6807.2000.
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