基质蛋白1：对甲型H5N1流感病毒不同毒株的计算机模拟比较研究
Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus.
作者信息
Anwar Tamanna, Lal Sunil K, Khan Asad U
机构信息
Distributed Information Sub-centre, Aligarh Muslim University, Aligarh 202002, India.
出版信息
Bioinformation. 2006 Nov 22;1(7):253-6. doi: 10.6026/97320630001253.
Abstract
The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.
摘要
流感病毒作为全球感染源的重要性已得到充分认可。流感病毒的特定突变和进化难以预测。我们使用生物信息学开发的预测工具，研究了甲型H5N1流感病毒基质蛋白1（M1）的特定突变及其相关特性。我们注意到并记录了突变位点处疏水性、极性和二级结构的变化，以深入了解其感染机制。
相似文献
1
Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus.基质蛋白1：对甲型H5N1流感病毒不同毒株的计算机模拟比较研究
Bioinformation. 2006 Nov 22;1(7):253-6. doi: 10.6026/97320630001253.
2
3
Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation.携带 K193T 突变的可经雪貂传播的 H5N1 对人类型受体的结合增强。
J Virol. 2018 Apr 27;92(10). doi: 10.1128/JVI.02016-17. Print 2018 May 15.
4
Mosaic H5 Hemagglutinin Provides Broad Humoral and Cellular Immune Responses against Influenza Viruses.嵌合H5血凝素可引发针对流感病毒的广泛体液免疫和细胞免疫反应。
J Virol. 2016 Jul 11;90(15):6771-6783. doi: 10.1128/JVI.00730-16. Print 2016 Aug 1.
5
Molecular dynamics simulation of the effects of single (S221P) and double (S221P and K216E) mutations in the hemagglutinin protein of influenza A H5N1 virus: a study on host receptor specificity.甲型H5N1流感病毒血凝素蛋白单突变（S221P）和双突变（S221P与K216E）影响的分子动力学模拟：宿主受体特异性研究
J Biomol Struct Dyn. 2016 Sep;34(9):2054-67. doi: 10.1080/07391102.2015.1106341. Epub 2015 Nov 26.
6
Highly Pathogenic H5N1 and Novel H7N9 Influenza A Viruses Induce More Profound Proteomic Host Responses than Seasonal and Pandemic H1N1 Strains.高致病性H5N1和新型H7N9甲型流感病毒比季节性和大流行性H1N1毒株引发更深刻的蛋白质组学宿主反应。
J Proteome Res. 2015 Nov 6;14(11):4511-23. doi: 10.1021/acs.jproteome.5b00196. Epub 2015 Oct 9.
7
Phylodynamics of avian influenza clade 2.2.1 H5N1 viruses in Egypt.埃及2.2.1进化枝H5N1禽流感病毒的系统动力学
Virol J. 2016 Mar 22;13:49. doi: 10.1186/s12985-016-0477-7.
8
9
Cross-Reactive Neuraminidase-Inhibiting Antibodies Elicited by Immunization with Recombinant Neuraminidase Proteins of H5N1 and Pandemic H1N1 Influenza A Viruses.用H5N1和甲型H1N1大流行性流感病毒的重组神经氨酸酶蛋白免疫引发的交叉反应性神经氨酸酶抑制抗体。
J Virol. 2015 Jul;89(14):7224-34. doi: 10.1128/JVI.00585-15. Epub 2015 May 6.
10
[Subcloning of M1 gene fragment of H5N1 influenza virus and its expression in Escherichia coli].H5N1流感病毒M1基因片段的亚克隆及其在大肠杆菌中的表达
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):254-7.
引用本文的文献
1
Molecular detection of influenza A(H1N1)pdm09 viruses with M genes from human pandemic strains among Nigerian pigs, 2013-2015: implications and associated risk factors.2013 - 2015年尼日利亚猪群中甲型H1N1pdm09流感病毒与来自人类大流行毒株M基因的分子检测：影响及相关危险因素
Epidemiol Infect. 2017 Dec;145(16):3345-3360. doi: 10.1017/S0950268817002503. Epub 2017 Nov 23.
2
Efficacy of neuraminidase (NA) inhibitors against H1N1 strains of different geographical regions: an in silico approach.神经氨酸酶（NA）抑制剂对不同地理区域 H1N1 株的疗效：一种计算机模拟方法。
Indian J Microbiol. 2009 Dec;49(4):370-6. doi: 10.1007/s12088-009-0065-2. Epub 2010 Jan 7.
3
Phylogenetic analysis of surface proteins of novel H1N1 virus isolated from 2009 pandemic.对2009年大流行中分离出的新型H1N1病毒表面蛋白的系统发育分析。
Bioinformation. 2009 Sep 30;4(3):94-7. doi: 10.6026/97320630004094.
4
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus.H9N2和H5N1禽流感病毒PB2蛋白分析
Bioinformation. 2008;3(1):41-6. doi: 10.6026/97320630003041. Epub 2008 Sep 22.
5
Identification of amino acid substitutions in avian influenza virus (H5N1) matrix protein 1 by using nanoelectrospray MS and MS/MS.
J Am Soc Mass Spectrom. 2009 Feb;20(2):312-20. doi: 10.1016/j.jasms.2008.10.010. Epub 2008 Oct 18.
本文引用的文献
1
MAP MUTATION: a program for analyzing mutations in protein sequences.MAP突变：一个用于分析蛋白质序列突变的程序。
Bioinformation. 2006 Feb 20;1(3):92-3. doi: 10.6026/97320630001092.
2
3
Human infection by avian influenza A H5N1.人感染甲型H5N1禽流感。
Hong Kong Med J. 2005 Jun;11(3):189-99.
4
A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence.乙型流感病毒基质蛋白M1的C末端结构域中的单个氨基酸变化赋予了对小鼠的适应性和毒力。
Virology. 2005 Jun 5;336(2):318-26. doi: 10.1016/j.virol.2005.03.028.
5
Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.甲型流感病毒A/WSN/33株基质基因的减毒突变
J Virol. 2005 Feb;79(3):1918-23. doi: 10.1128/JVI.79.3.1918-1923.2005.
6
Re-emergence of fatal human influenza A subtype H5N1 disease.致命的甲型H5N1流感病毒引起的人类疾病再度出现。
Lancet. 2004 Feb 21;363(9409):617-9. doi: 10.1016/S0140-6736(04)15595-5.
7
Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997.1997年香港甲型H5N1禽流感病毒感染暴发。
Clin Infect Dis. 2002 May 1;34 Suppl 2:S58-64. doi: 10.1086/338820.
8
Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export.流感病毒基质蛋白和病毒RNA对核糖核蛋白形成及核输出的影响。
Virology. 2001 Sep 1;287(2):405-16. doi: 10.1006/viro.2001.1067.
9
In vitro dissection of the membrane and RNP binding activities of influenza virus M1 protein.流感病毒M1蛋白膜结合活性和核糖核蛋白结合活性的体外剖析
Virology. 2001 Mar 1;281(1):102-8. doi: 10.1006/viro.2000.0804.
10
Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes.甲型流感病毒（H3N2）核蛋白中的抗原漂移以及逃避细胞毒性T淋巴细胞的识别。
J Virol. 2000 Aug;74(15):6800-7. doi: 10.1128/jvi.74.15.6800-6807.2000.
Zotero 插件