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本文引用的文献

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MAP MUTATION: a program for analyzing mutations in protein sequences.MAP突变：一个用于分析蛋白质序列突变的程序。
Bioinformation. 2006 Feb 20;1(3):92-3. doi: 10.6026/97320630001092.
2
In silico analysis of genes nucleoprotein, neuraminidase and hemagglutinin: a comparative study on different strains of influenza A (Bird flu) virus sub-type H5N1.核蛋白、神经氨酸酶和血凝素基因的计算机模拟分析：对甲型流感（禽流感）病毒H5N1亚型不同毒株的比较研究
In Silico Biol. 2006;6(3):161-8.
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Human infection by avian influenza A H5N1.人感染甲型H5N1禽流感。
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A single amino acid change in the C-terminal domain of the matrix protein M1 of influenza B virus confers mouse adaptation and virulence.乙型流感病毒基质蛋白M1的C末端结构域中的单个氨基酸变化赋予了对小鼠的适应性和毒力。
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Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.甲型流感病毒A/WSN/33株基质基因的减毒突变
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Re-emergence of fatal human influenza A subtype H5N1 disease.致命的甲型H5N1流感病毒引起的人类疾病再度出现。
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Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997.1997年香港甲型H5N1禽流感病毒感染暴发。
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Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export.流感病毒基质蛋白和病毒RNA对核糖核蛋白形成及核输出的影响。
Virology. 2001 Sep 1;287(2):405-16. doi: 10.1006/viro.2001.1067.
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In vitro dissection of the membrane and RNP binding activities of influenza virus M1 protein.流感病毒M1蛋白膜结合活性和核糖核蛋白结合活性的体外剖析
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Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes.甲型流感病毒（H3N2）核蛋白中的抗原漂移以及逃避细胞毒性T淋巴细胞的识别。
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基质蛋白1：对甲型H5N1流感病毒不同毒株的计算机模拟比较研究

Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus.

作者信息

Anwar Tamanna, Lal Sunil K, Khan Asad U

机构信息

Distributed Information Sub-centre, Aligarh Muslim University, Aligarh 202002, India.

出版信息

Bioinformation. 2006 Nov 22;1(7):253-6. doi: 10.6026/97320630001253.

DOI:10.6026/97320630001253
PMID:17597902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1891697/
Abstract

The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.

摘要

流感病毒作为全球感染源的重要性已得到充分认可。流感病毒的特定突变和进化难以预测。我们使用生物信息学开发的预测工具，研究了甲型H5N1流感病毒基质蛋白1（M1）的特定突变及其相关特性。我们注意到并记录了突变位点处疏水性、极性和二级结构的变化，以深入了解其感染机制。