对2009年大流行中分离出的新型H1N1病毒表面蛋白的系统发育分析。
Phylogenetic analysis of surface proteins of novel H1N1 virus isolated from 2009 pandemic.
作者信息
Danishuddin Mohd, Khan Shahper N, Khan Asad U
机构信息
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, India.
出版信息
Bioinformation. 2009 Sep 30;4(3):94-7. doi: 10.6026/97320630004094.
Swine Influenza Virus (H1N1) is a known causative agent of swine flu. Transmission of Swine Influenza Virus form pig to human is not a common event and may not always cause human influenza. The 2009 outbreak by subtype H1N1 in humans is due to transfer of Swine Influenza Virus from pig to human. Thus to analyze the origin of this novel virus we compared two surface proteins (HA and NA) with influenza viruses of swine, avian and humans isolates recovered from 1918 to 2008 outbreaks. Phylogenetic analyses of hemagglutinin gene from 2009 pandemic found to be clustered with swine influenza virus (H1N2) circulated in U.S.A during the 1999-2004 outbreaks. Whereas, neuraminidase gene was clustered with H1N1 strains isolated from Europe and Asia during 1992-2007 outbreaks. This study concludes that the new H1N1 strain appeared in 2009 outbreak with high pathogenicity to human was originated as result of re-assortment (exchange of gene). Moreover, our data also suggest that the virus will remain sensitive to the pre-existing therapeutic strategies.
甲型H1N1流感病毒是猪流感的已知病原体。甲型H1N1流感病毒从猪传播给人类并非常见事件，也不一定总会引发人类流感。2009年H1N1亚型在人类中的爆发是由于甲型H1N1流感病毒从猪传播给了人类。因此，为了分析这种新型病毒的起源，我们将两种表面蛋白（血凝素和神经氨酸酶）与1918年至2008年爆发疫情期间从猪、禽类和人类分离出的流感病毒进行了比较。对2009年大流行的血凝素基因进行系统发育分析发现，它与1999年至2004年美国爆发疫情期间传播的猪流感病毒（H1N2）聚集在一起。而神经氨酸酶基因则与1992年至2007年爆发疫情期间从欧洲和亚洲分离出的H1N1毒株聚集在一起。本研究得出结论，2009年爆发疫情时出现的对人类具有高致病性的新型H1N1毒株是基因重配（基因交换）的结果。此外，我们的数据还表明，该病毒对现有的治疗策略仍将保持敏感。
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