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[外周动脉疾病患者的无症状缺血性心脏病。418例患者群体的筛查及5年预后]

[Silent ischemic heart diseases in patients with peripheral arterial diseases. Screening and 5-year prognosis in a population of 418 patients].

作者信息

Ponsonnaille J, Fabry R, Chapou M, Lipiecki J, Delahaye R, Duchene-Marullaz P

机构信息

Service de cardiologie, CHRU hôpital Saint-Jacques, Clermont-Ferrand.

出版信息

Arch Mal Coeur Vaiss. 1991 Oct;84(10):1407-11.

PMID:1759892
Abstract

Silent ischaemic heart disease was looked for by exercise stress testing in 418 patients with chronic obliterative arterial disease of the lower limbs with no clinical or electrocardiographic signs of myocardial ischaemia. In the initial work-up, 6.2% of patients had a positive exercise test and the results were suspect in 9.2% of patients. These patients were followed up for 5 years. There were 42 deaths (10%). The cause of death was cardiovascular in 53.7% of cases (myocardial infarction 40.4%) and malignant disease in 35.7%. During the 5 year follow-up, ischaemic heart disease present as angina pectoris or myocardial infarction in 115 cases (27.5%). Patients who had a positive exercise stress test initially had a particularly high death rate (23%) and developed clinical signs of coronary insufficiency in 57.5% of cases. On the other hand, the peripheral vascular complications were relatively rare in this series: cerebrovascular accidents: 1.4%; retinal vascular accident: 1.1%; carotid surgery: 1.6%; lower limb amputation: 1.9%; lower limb vascular surgery: 17.7%. Silent ischaemic heart disease is very prevalent in patients with obliterative arterial disease of the lower limbs and is a main vital prognostic factor in these patients. These results confirm the need for a complete cardiovascular check-up in all patients with peripheral arterial disease.

摘要

对418例下肢慢性闭塞性动脉疾病患者进行运动负荷试验,以筛查无症状性缺血性心脏病,这些患者无心肌缺血的临床或心电图表现。在初始检查中,6.2%的患者运动试验呈阳性,9.2%的患者结果可疑。对这些患者进行了5年的随访。共有42例死亡(10%)。53.7%的病例死亡原因是心血管疾病(心肌梗死占40.4%),35.7%是恶性疾病。在5年随访期间,115例(27.5%)出现了作为心绞痛或心肌梗死的缺血性心脏病。最初运动负荷试验呈阳性的患者死亡率特别高(23%),57.5%的病例出现了冠状动脉供血不足的临床症状。另一方面,该系列中周围血管并发症相对较少:脑血管意外:1.4%;视网膜血管意外:1.1%;颈动脉手术:1.6%;下肢截肢:1.9%;下肢血管手术:17.7%。无症状性缺血性心脏病在下肢闭塞性动脉疾病患者中非常普遍,是这些患者重要的预后因素。这些结果证实了对所有外周动脉疾病患者进行全面心血管检查的必要性。

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