Omo-Aghoja I O, Okonofua F E
Department of Obstetrics and Gynaecology, College of Health Sciences, Delta State University, Abraka.
Niger Postgrad Med J. 2007 Jun;14(2):151-4.
To evaluate the cases of sickle cell anaemia in obstetric practice, and to highlight their problems in pregnancy as well as their contribution to maternal and foetal outcome in Nigeria. We believe that the findings would be useful for designing interventions to reduce the obstetric burden of sickle cell disease.
The service delivery record of 42 pregnancies in 39 patients with sickle cell disease was retrospectively reviewed at the University of Benin Teaching Hospital (UBTH) between January 2000 and December 2004.
The incidence of sickle cell disease in the study was 8.7/1000 deliveries. Nearly 62% of the patients were aged 25-34 years, while 76.2% were either nulliparous (Para O) or primiparous (Para 1). There was one grandmultipara (2.38%). Anaemia (95.25%), Malaria (33.33%), Bone pain crisis (23.81%), and pneumonia (19.05%) in that order of frequency were the most common complications of pregnancy. The perinatal mortality rate was 250 per 1000 births while the maternal mortality rate was 47.6 per 1000 pregnancies. At delivery, 20% of cases had caesarean section (5% elective and 15% emergency) and the instrumental interventions include 12.5% vacuum and 27.5% forceps respectively.
Early booking, good antenatal care and supervised hospital delivery produced a better obstetric outcome.
评估产科实践中镰状细胞贫血病例，强调其在妊娠期间的问题以及对尼日利亚孕产妇和胎儿结局的影响。我们认为，这些研究结果将有助于设计干预措施，以减轻镰状细胞病的产科负担。
回顾性分析了2000年1月至2004年12月期间在贝宁大学教学医院（UBTH）的39例镰状细胞病患者的42次妊娠服务记录。
该研究中镰状细胞病的发病率为8.7/1000分娩。近62%的患者年龄在25 - 34岁之间，76.2%为未产妇（产次0）或初产妇（产次1）。有1例多产妇（2.38%）。妊娠最常见的并发症依次为贫血（95.25%）、疟疾（33.33%）、骨痛危象（23.81%）和肺炎（19.05%）。围产儿死亡率为每1000例出生250例，孕产妇死亡率为每1000例妊娠47.6例。分娩时，20%的病例行剖宫产（5%为选择性剖宫产，15%为急诊剖宫产），器械助产分别包括12.5%的真空吸引和27.5%的产钳助产。
早期预约、良好的产前护理和医院监督下的分娩可产生更好的产科结局。
