Roznovský L, Kloudová A, Kabieszová L, Dedek V, Orságová I, Zjevíková A
Department of Infectious Diseases, University Hospital Ostrava, 17. listopadu 1790, 708 00 Ostrava, Czech Republic.
Klin Mikrobiol Infekc Lek. 2007 Apr;13(2):76-9.
Liver transplantation was performed in 3 patients with hepatitis B infection in 1999-2004 years. Combination of hepatitis B immunoglobulin (HBIg) and lamivudine are used for prevention of hepatitis B recurrence. HBIg is administered in dose 2 000 international units (IU) with tendency to maintain anti-HBs antibodies above 100 IU/litre. Average interval between HBIg administrations was 22, 32 and 32 days, yearly price of treatment was 0.45-0.65 million Czech crowns. Three patients with HBIg and lamivudine therapy are still without recurrence of hepatitis B at the end of 2006 year.
1999年至2004年期间,对3例乙肝感染患者实施了肝移植手术。采用乙肝免疫球蛋白(HBIg)和拉米夫定联合用药预防乙肝复发。HBIg的给药剂量为2000国际单位(IU),并倾向于将抗-HBs抗体维持在100 IU/升以上。HBIg给药的平均间隔时间分别为22天、32天和32天,每年的治疗费用为45万至65万捷克克朗。截至2006年底,接受HBIg和拉米夫定治疗的3例患者仍未出现乙肝复发。