Zeeuws Inge, Soetens Eric
Vrije Universiteit Brussel, Brussel, Belgium.
Hum Psychopharmacol. 2007 Jul;22(5):279-87. doi: 10.1002/hup.848.
An improved long-term retention of verbal memory was observed after an acute D-amphetamine administration. It was proposed that D-amphetamine modulates consolidation, but a possible drug effect on retrieval could not be rejected.
We want to provide additional support for the consolidation hypothesis, and investigate whether an influence on intervening retrieval can be refuted.
Thirty-six male paid volunteers participated in a double blind, counterbalanced, placebo-controlled design in which the number of intermediate free recall tests was manipulated.
A significant D-amphetamine facilitation effect on recall performance emerged 1 h and 1 day after list learning. In line with the consolidation hypothesis, no effect was found on immediate tests. Importantly, the number of intermediate retrievals did not affect the magnitude of the drug effect, suggesting that the D-amphetamine facilitation effect is independent of retrieval.
The D-amphetamine facilitation effect on verbal memory does not involve a modulation of the initial encoding or short-term memory (STM) processes. Moreover, the drug does not enhance long-term retention by acting on intervening retrieval processes. The current findings are in line with the conjecture of an involvement of the consolidation process in the D-amphetamine facilitation effect on verbal memory in healthy humans.
急性给予右旋苯丙胺后观察到言语记忆的长期保持得到改善。有人提出右旋苯丙胺调节巩固过程，但不能排除药物对提取的可能影响。
我们想为巩固假说提供额外支持，并研究是否可以排除对中间提取的影响。
36名男性有偿志愿者参与了一项双盲、平衡、安慰剂对照设计，其中操纵了中间自由回忆测试的次数。
在列表学习后1小时和1天，右旋苯丙胺对回忆表现有显著的促进作用。与巩固假说一致，即时测试未发现影响。重要的是，中间提取的次数不影响药物作用的大小，表明右旋苯丙胺的促进作用与提取无关。
右旋苯丙胺对言语记忆的促进作用不涉及对初始编码或短期记忆（STM）过程的调节。此外，该药物不会通过作用于中间提取过程来增强长期保持。目前的研究结果与巩固过程参与右旋苯丙胺对健康人类言语记忆促进作用的推测一致。
