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[从重症监护病房住院患者中分离出的细菌菌株的传染性和抗生素耐药性]

[Infectivity and resistance to antibiotics of bacterial strains isolated from patients hospitalised in intensive care units].

作者信息

Wojnicz Dorota, Korzekwa Kamila, Kakol Anna, Doroszkiewicz W

机构信息

Katedra i Zakład Biologii i Parazytologii Lekarskiej AM we Wrocławiu.

出版信息

Med Dosw Mikrobiol. 2007;59(1):75-84.

Abstract

The aim of this study was to evaluate the frequency of isolation and antimicrobial resistance testing of bacterial strains isolated from clinical specimens from patients hospitalized in three Intensive Care Units in Wrocław. The susceptibility of bacteria (107 strains) to selected antibiotics was determined. The results clearly show that non-fermentative rods were identified as the main agents causing pneumonia (58% of isolates). The second commonest pathogens were Gram-positive cocci (29%). The P. aeruginosa and E. cloacae strains were resistant to ampicillin, amoxicillin/clavulanate, cefuroxime and cefotaxime. All isolates of A. baumanii were susceptible only to imipenem. The rods of K. pneumoniae and E. coli were resistant to ampicillin, about 55% strains of both bacteria were sensitive to other antibiotics, except piperacillin/tazobactam, imipenem and ciprofloxacin. About 90% of methicillin resistant S. epidermidis strains were resistant to all antibiotics, except vancomycin (100% isolates were sensitive). ESBL were detected among E. cloace, K. pneumoniae and E. coli. We found P. aeruginosa rods producing MBL.

摘要

本研究的目的是评估从弗罗茨瓦夫三个重症监护病房住院患者的临床标本中分离出的细菌菌株的分离频率和抗菌药物敏感性测试情况。测定了细菌(107株)对选定抗生素的敏感性。结果清楚地表明,非发酵菌被确定为引起肺炎的主要病原体(占分离株的58%)。第二常见的病原体是革兰氏阳性球菌(29%)。铜绿假单胞菌和阴沟肠杆菌菌株对氨苄西林、阿莫西林/克拉维酸、头孢呋辛和头孢噻肟耐药。所有鲍曼不动杆菌分离株仅对亚胺培南敏感。肺炎克雷伯菌和大肠杆菌的杆菌对氨苄西林耐药,两种细菌约55%的菌株对其他抗生素敏感,但哌拉西林/他唑巴坦、亚胺培南和环丙沙星除外。约90%的耐甲氧西林表皮葡萄球菌菌株对所有抗生素耐药,但万古霉素除外(100%的分离株敏感)。在阴沟肠杆菌、肺炎克雷伯菌和大肠杆菌中检测到超广谱β-内酰胺酶。我们发现铜绿假单胞菌杆菌产生金属β-内酰胺酶。

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