眼部药物向前节的错误递送。

Mist delivery of eye medication to the anterior segment.

作者信息

Collins James F, Dartt Darlene A, Dana Reza

机构信息

Stony Brook University School of Medicine, Stony Brook, New York, USA.

出版信息

Am J Ophthalmol. 2007 Jul;144(1):137-9. doi: 10.1016/j.ajo.2007.03.022.

DOI:10.1016/j.ajo.2007.03.022

PMID:17601439

Abstract

PURPOSE

To compare the mydriatic efficacies of mist and drop delivery of tropicamide 1.0%.

DESIGN

Randomized, masked, active, controlled clinical trial.

METHODS

One hundred subjects were randomized to receive small-volume (6 microl) mist administration of tropicamide 1.0% in one eye and either nothing or a conventional drop (30 microl) of the same solution in the fellow eye.

RESULTS

Comparing misted eyes with untreated eyes in the same subjects, the mean maximal increase in pupil diameter in the misted eyes was 2.02 mm and was 0.25 mm in the fellow eyes. The difference is statistically significant (P <or= .001) Comparing mist-treated eyes with drop-treated eyes in the same subjects, the mean maximal increase in pupil diameter in the misted eyes was 1.98 mm and was 2.11 mm in the drop-treated eyes. The difference was not statistically significant (P = .051).

CONCLUSIONS

Small-volume mist and conventional drop delivery of tropicamide 1.0% were shown to be similar in mydriatic effectiveness.

摘要

目的

比较1.0%托吡卡胺喷雾给药和滴眼给药的散瞳效果。

设计

随机、盲法、活性药物对照临床试验。

方法

100名受试者被随机分配，一只眼睛接受小容量（6微升）1.0%托吡卡胺喷雾给药，另一只眼睛不接受任何处理或接受相同溶液的传统滴眼（30微升）。

结果

在同一受试者中，将喷雾给药的眼睛与未治疗的眼睛进行比较，喷雾给药眼睛的瞳孔直径平均最大增加量为2.02毫米，另一只眼睛为0.25毫米。差异具有统计学意义（P≤0.001）。在同一受试者中，将喷雾给药的眼睛与滴眼给药的眼睛进行比较，喷雾给药眼睛的瞳孔直径平均最大增加量为1.98毫米，滴眼给药眼睛为2.11毫米。差异无统计学意义（P = 0.051）。