Collins James F, Dartt Darlene A, Dana Reza
Stony Brook University School of Medicine, Stony Brook, New York, USA.
Am J Ophthalmol. 2007 Jul;144(1):137-9. doi: 10.1016/j.ajo.2007.03.022.
To compare the mydriatic efficacies of mist and drop delivery of tropicamide 1.0%.
Randomized, masked, active, controlled clinical trial.
One hundred subjects were randomized to receive small-volume (6 microl) mist administration of tropicamide 1.0% in one eye and either nothing or a conventional drop (30 microl) of the same solution in the fellow eye.
Comparing misted eyes with untreated eyes in the same subjects, the mean maximal increase in pupil diameter in the misted eyes was 2.02 mm and was 0.25 mm in the fellow eyes. The difference is statistically significant (P <or= .001) Comparing mist-treated eyes with drop-treated eyes in the same subjects, the mean maximal increase in pupil diameter in the misted eyes was 1.98 mm and was 2.11 mm in the drop-treated eyes. The difference was not statistically significant (P = .051).
Small-volume mist and conventional drop delivery of tropicamide 1.0% were shown to be similar in mydriatic effectiveness.
比较1.0%托吡卡胺喷雾给药和滴眼给药的散瞳效果。
随机、盲法、活性药物对照临床试验。
100名受试者被随机分配，一只眼睛接受小容量（6微升）1.0%托吡卡胺喷雾给药，另一只眼睛不接受任何处理或接受相同溶液的传统滴眼（30微升）。
在同一受试者中，将喷雾给药的眼睛与未治疗的眼睛进行比较，喷雾给药眼睛的瞳孔直径平均最大增加量为2.02毫米，另一只眼睛为0.25毫米。差异具有统计学意义（P≤0.001）。在同一受试者中，将喷雾给药的眼睛与滴眼给药的眼睛进行比较，喷雾给药眼睛的瞳孔直径平均最大增加量为1.98毫米，滴眼给药眼睛为2.11毫米。差异无统计学意义（P = 0.051）。
1.0%托吡卡胺小容量喷雾给药和传统滴眼给药的散瞳效果相似。
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