Walshaw M J, Lim R, Ahmad R, Hind C R
Department of Medicine, Royal Liverpool Hospital, University of Liverpool, UK.
Blood Purif. 1991;9(2):70-3. doi: 10.1159/000169999.
Trapping of neutrophils within the lung occurs in patients undergoing haemodialysis and is also a possible mechanism in the pathogenesis of bronchial hyper-responsiveness. Falls in peak expiratory flow rate occur in most dialysis patients, and some develop overt asthmatic symptoms. To see whether these changes in airway function are secondary to increases in bronchial reactivity during haemodialysis, we therefore performed histamine challenge testing in 6 non-asthmatic patients before and after haemodialysis. No change in reactivity was observed, suggesting that haemodialysis does not commonly result in bronchial hyper-reactivity in non-asthmatic individuals.
接受血液透析的患者会出现中性粒细胞在肺内滞留的情况，这也是支气管高反应性发病机制中的一种可能机制。大多数透析患者的呼气峰值流速会下降，一些患者会出现明显的哮喘症状。因此，为了探究这些气道功能变化是否继发于血液透析期间支气管反应性的增加，我们对6名非哮喘患者在血液透析前后进行了组胺激发试验。未观察到反应性变化，这表明血液透析在非哮喘个体中通常不会导致支气管高反应性。
