Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: a preliminary trial.

作者信息

Tsukahara Yasutomo, Honda Shigeru, Imai Hisanori, Kondo Naoshi, Fujii Shigeki, Yokoyama Naoki, Hirata Akira, Kawaji Takahiro, Fukushima Mikiko, Tanihara Hidenobu, Negi Akira

机构信息

Division of Ophthalmology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, Japan.

出版信息

Am J Ophthalmol. 2007 Jul;144(1):139-41. doi: 10.1016/j.ajo.2007.03.020.

DOI:10.1016/j.ajo.2007.03.020

PMID:17601440

Abstract

PURPOSE

To evaluate the efficacy of autologous plasmin (AP)-assisted vitrectomy for stage 5 retinopathy of prematurity (ROP).

DESIGN

Interventional case series.

METHODS

Six consecutive eyes of four children with stage 5 ROP were treated. The patients' ages at the surgery ranged from five to eight months after birth. Four eyes showed closed-closed configuration and two eyes showed open-open configuration. After lensectomy and dissection of the anterior proliferative membrane, 0.03 to 0.22 International Unit (IU) of AP was administrated into the vitreous cavity. After 15 to 30 minutes of incubation, the proliferative membrane was treated.

RESULTS

The proliferative membrane was removed successfully without iatrogenic retinal break. Complete reattachment of the posterior pole retina was achieved in all six eyes (100%). No obvious complication was observed in the follow-up period, which ranged from 11 to 14 months.