Computation of release kinetics of isoniazid microcapsules.

Isoniazid is a drug of choice for intermittent chemotherapy of tuberculosis. It has been microencapsulated by emulsification followed by solvent evaporation technique using Eudragit RS 100 as polymer where free flowing, spherical and discrete microcapsules have been formed as obtained by SEM. The drug release data have been computed in the light of various kinetic models, where it is found that the matrix release mechanism predominates over the first and zero order mechanism for isoniazid microcapsules, even if the sizes and drug polymer ratio of the microcapsules were varied.