儿茶酚-O-甲基转移酶Val158Met多态性与精神分裂症的广泛认知功能无关。
The catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.
作者信息
Dickerson Faith B, Boronow John J, Stallings Cassie, Origoni Andrea E, Sullens Anne, Yolken Robert H
机构信息
Stanley Research Program at Sheppard Pratt, Sheppard Pratt Health System, Baltimore, MD 21204, USA.
出版信息
Schizophr Res. 2007 Nov;96(1-3):87-92. doi: 10.1016/j.schres.2007.05.021. Epub 2007 Jul 2.
BACKGROUND
A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. The association between the COMT polymorphism and other cognitive domains has been the focus of only limited investigation.
METHODS
We measured COMT Val158Met genotypes in N=364 individuals with schizophrenia. Cognitive functioning was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We employed univariate and multivariate analyses of variance to determine the association between COMT genotypes and the RBANS index and individual test scores.
RESULTS
There was no significant association between the COMT Val158Met genotypes and any of the RBANS index or individual test scores measured in either univariate or multivariate analyses (all p>.3).
CONCLUSION
Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.
背景
儿茶酚-O-甲基转移酶基因在编码蛋白质第158位氨基酸缬氨酸（Val）或蛋氨酸（Met）的核苷酸处存在缬氨酸/蛋氨酸多态性（COMT Val158Met多态性），一些研究表明该多态性与精神分裂症患者执行功能缺陷有关。COMT多态性与其他认知领域之间的关联仅在有限的研究中受到关注。
方法
我们对364例精神分裂症患者进行了COMT Val158Met基因分型。使用可重复神经心理状态评估量表（RBANS）评估认知功能。我们采用单因素和多因素方差分析来确定COMT基因型与RBANS指数及各个测试分数之间的关联。
结果
在单因素或多因素分析中，COMT Val158Met基因型与任何RBANS指数或各个测试分数之间均无显著关联（所有p>.3）。
结论
基于我们样本的结果，儿茶酚-O-甲基转移酶Val158Met多态性与精神分裂症患者广泛的认知功能无关。
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