N-乙酰半胱氨酸——一种治疗半胱氨酸/谷胱甘肽缺乏症的安全解毒剂。
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
作者信息
Atkuri Kondala R, Mantovani John J, Herzenberg Leonard A, Herzenberg Leonore A
机构信息
Department of Genetics, School of Medicine, Stanford University, B007 Beckman Center, 279 Campus Drive, Stanford University, CA 94305-5318, United States.
出版信息
Curr Opin Pharmacol. 2007 Aug;7(4):355-9. doi: 10.1016/j.coph.2007.04.005. Epub 2007 Jun 29.
Abstract
Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. Over two-thirds of 46 placebo-controlled clinical trials with orally administered NAC have indicated beneficial effects of NAC measured either as trial endpoints or as general measures of improvement in quality of life and well-being of the patients.
摘要
谷胱甘肽（GSH）缺乏与多种病理状况相关。给予N-乙酰半胱氨酸（NAC），一种半胱氨酸前体药物，可补充细胞内GSH水平。NAC以其对抗对乙酰氨基酚毒性的能力而闻名，是一种安全、耐受性良好的治疗半胱氨酸/GSH缺乏的解毒剂。NAC已成功用于治疗多种感染、遗传缺陷和代谢紊乱中的GSH缺乏，包括HIV感染和慢性阻塞性肺疾病（COPD）。在46项口服NAC的安慰剂对照临床试验中，超过三分之二的试验表明，以试验终点或患者生活质量和幸福感改善的一般指标衡量，NAC具有有益效果。
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