砷化镓（808纳米）激光照射可增强培养的人类神经元细胞中的三磷酸腺苷（ATP）生成。
Ga-As (808 nm) laser irradiation enhances ATP production in human neuronal cells in culture.
作者信息
Oron U, Ilic S, De Taboada L, Streeter J
机构信息
Photothera Inc., Carlsbad, California, USA.
出版信息
Photomed Laser Surg. 2007 Jun;25(3):180-2. doi: 10.1089/pho.2007.2064.
OBJECTIVE
The aim of the present study was to investigate whether Ga-As laser irradiation can enhance adenosine triphosphate (ATP) production in normal human neural progenitor (NHNP) cells in culture.
METHODS
NHNP were grown in tissue culture and were treated by Ga-As laser (808 nm, 50 mW/cm(2), 0.05 J/cm(2)), and ATP was determined at 10 min after laser application.
RESULTS
The quantity of ATP in laser-treated cells was 7513 +/- 970 units, which was significantly higher (p < 0.05) than the non-treated cells, which comprised 3808 +/- 539 ATP units.
CONCLUSION
Laser application to NHNP cells significantly increases ATP production in these cells. These findings may explain the beneficial effects of low-level laser therapy (LLLT) in stroked rats. Tissue culture of NHNP cells might offer a good model to study the mechanisms associated with promotion of ATP production in the nervous system by LLLT.
目的
本研究旨在探讨砷化镓激光照射是否能增强培养的正常人神经祖细胞（NHNP）中三磷酸腺苷（ATP）的产生。
方法
将NHNP细胞在组织培养中生长，并用砷化镓激光（808纳米，50毫瓦/平方厘米，0.05焦耳/平方厘米）处理，在激光照射后10分钟测定ATP含量。
结果
激光处理细胞中的ATP含量为7513±970单位，显著高于未处理细胞（3808±539个ATP单位）（p<0.05）。
结论
对NHNP细胞进行激光照射可显著增加这些细胞中ATP的产生。这些发现可能解释了低强度激光疗法（LLLT）对中风大鼠的有益作用。NHNP细胞的组织培养可能为研究LLLT促进神经系统中ATP产生相关机制提供一个良好的模型。
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