年龄、性别与特定分级的结直肠癌第二原发癌风险：女性激素保护作用的证据
Age, sex and the risk of grade-specific second primary colorectal cancer: evidence for the protective effect of female hormone.
作者信息
Liang Wenbin
机构信息
School of Public Health, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia.
出版信息
Eur J Cancer. 2007 Aug;43(12):1856-61. doi: 10.1016/j.ejca.2007.05.015. Epub 2007 Jul 2.
AIM
To investigate the interaction effects of age and sex on the risk of grade-specific second primary colorectal cancer (SPCRC).
METHOD
This is a retrospective cohort study, using registry data covering the period 1973-2003 from the SEER program, National Cancer Institute. The sex-age-specific incidence rates of Grade 1, Grade 2 and Grade 3 second primary colorectal cancer (SPCRC) were calculated. Poisson regression models were used to estimate the interaction effects between sex and age.
RESULTS
The sex-age-specific incidence rates of Grade 1, Grade 2, and Grade 3 second primary colorectal cancer (SPCRC) increased gradually with age, especially in females. There was a significant interaction effect between sex and age on the risk of Grade 3 second primary colon cancer.
CONCLUSION
Decrease in female hormone level since menopausal age may increase the risk of a second primary colon cancer, especially a cancer with poorer differentiation.
目的
探讨年龄和性别对特定分级的结直肠癌第二原发癌（SPCRC）风险的交互作用。
方法
这是一项回顾性队列研究，使用了美国国立癌症研究所监测、流行病学和最终结果（SEER）项目1973 - 2003年期间的登记数据。计算了1级、2级和3级结直肠癌第二原发癌（SPCRC）的性别 - 年龄特异性发病率。采用泊松回归模型估计性别与年龄之间的交互作用。
结果
1级、2级和3级结直肠癌第二原发癌（SPCRC）的性别 - 年龄特异性发病率随年龄逐渐增加，尤其是在女性中。性别与年龄在3级结肠癌第二原发癌风险上存在显著的交互作用。
结论
绝经后女性激素水平下降可能增加结肠癌第二原发癌的风险，尤其是分化较差的癌症。
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