Bácsi Krisztián, Kósa János, Lazáry Aron, Balla Bernadett, Horváth Henrik, Takács István, Nagy Zsolt, Speer Gábor, Lakatos Péter
Semmelweis Egyetem, Altalános Orvostudományi Kar, I. Belgyógyászati Klinika, Korányi S. u. 2/a, 1083 Budapest.
Orv Hetil. 2007 Jul 8;148(27):1273-80. doi: 10.1556/OH.2007.28102.
CYP3A71C polymorphism has been shown to be associated with lower levels of serum dehydroepiandrosterone sulphate in men. The age-related decline of dehydroepiandrosterone sulphate levels is believed to contribute to the development of osteoporosis. We hypothesized that CYP3A71C may lead to bone loss through decreased levels of dehydroepiandrosterone sulphate in postmenopausal women.
319 postmenopausal women were studied and divided into two subgroups: 217 women with osteoporosis and 102 aged-matched women without osteoporosis. The CYP3A7*1C polymorphism was genotyped. Serum dehydroepiandrosterone sulphate levels and bone mineral density were measured.
Homozygous CYP3A71C carriers had significantly lower bone mineral density at lumbar spine than that of wild type (T-score with CYP3A71C mutant type: -3.27 +/- 1.02, T-score with wild type: -1.35 +/- 1.53, p = 0.041) after adjusting for age and DHEAS levels. No association was found between genotypes and dehydroepiandrosterone sulphate levels.
Our data suggest that CYP3A7 polymorphism might have an influence on bone mass at the lumbar spine independently of serum dehydroepiandrosterone sulphate concentrations.
研究表明，CYP3A71C基因多态性与男性血清硫酸脱氢表雄酮水平降低有关。硫酸脱氢表雄酮水平随年龄下降被认为与骨质疏松症的发生有关。我们推测，CYP3A71C可能通过降低绝经后女性硫酸脱氢表雄酮水平导致骨质流失。
对319名绝经后女性进行研究，并分为两个亚组：217名患有骨质疏松症的女性和102名年龄匹配的无骨质疏松症女性。对CYP3A7*1C基因多态性进行基因分型。测量血清硫酸脱氢表雄酮水平和骨密度。
在调整年龄和硫酸脱氢表雄酮水平后，CYP3A71C纯合子携带者腰椎骨密度显著低于野生型（CYP3A71C突变型T值：-3.27±1.02，野生型T值：-1.35±1.53，p = 0.041）。未发现基因型与硫酸脱氢表雄酮水平之间存在关联。
我们的数据表明，CYP3A7基因多态性可能独立于血清硫酸脱氢表雄酮浓度对腰椎骨量产生影响。
