Maller Jerome J, Daskalakis Z Jeff, Fitzgerald Paul B
Department of Psychological Medicine, Alfred Psychiatry Research Centre, The Alfred & Monash University, Melbourne Victoria, Australia.
Hippocampus. 2007;17(11):1023-7. doi: 10.1002/hipo.20339.
Studies of patients with major depression disorder (MDD) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD and control subjects, using a strict measurement protocol, in order to elucidate morphological-specific volumetric differences. Forty-five subjects with treatment-resistant MDD and 26 controls underwent psychiatric assessments and brain magnetic resonance imaging (MRI). The findings of this study indicate that (1) MDD results in reduced hippocampal volume, particularly in the tail section, (2) region of interest (ROI) estimation protocols and sample characteristics may help explain volumetric differences between previous MDD studies, and (3) specific ROI atrophy in treatment-resistant depression is influenced by sex.
对重度抑郁症（MDD）患者的研究显示海马体体积减小，但由于样本和测量差异，研究结果并不一致。当前研究旨在使用严格的测量方案，对大量MDD患者和对照受试者的该结构进行测量，以阐明形态学特异性体积差异。45名难治性MDD患者和26名对照受试者接受了精神评估和脑磁共振成像（MRI）。本研究结果表明：（1）MDD会导致海马体体积减小，尤其是在尾部；（2）感兴趣区域（ROI）估计方案和样本特征可能有助于解释先前MDD研究之间的体积差异；（3）难治性抑郁症中特定ROI萎缩受性别影响。
