Woodson B Tucker, Franco Rose
Division of Sleep Medicine, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin at Froedtert West, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
Otolaryngol Clin North Am. 2007 Aug;40(4):691-711. doi: 10.1016/j.otc.2007.04.002.
Obstructive sleep apnea (OSA) results from complex interactions between anatomy and physiology. A structurally small and abnormally collapsible upper airway predisposes to disease, and interacts with normal and pathologic physiologic mechanisms to determine severity of disease. Understanding the pathophysiology provides insight into airway collapse, and may improve treatment and lead to potential new medical and surgical treatments for OSA.
阻塞性睡眠呼吸暂停(OSA)是由解剖学和生理学之间的复杂相互作用引起的。结构上狭小且异常易塌陷的上呼吸道易引发该疾病,并与正常和病理生理机制相互作用以确定疾病的严重程度。了解病理生理学有助于深入了解气道塌陷,可能改善治疗方法,并为OSA带来潜在的新药物和手术治疗手段。