Hinshaw Lisa B, Jackson Sharon A, Chen Michael Y
Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
J Clin Epidemiol. 2007 Aug;60(8):853-7. doi: 10.1016/j.jclinepi.2006.11.005. Epub 2007 Mar 26.
To analyze advertising, recruitment methods, and study participant demographics for the National Lung Screening Trial (NLST) site at Wake Forest University School of Medicine to define efficient ways to recruit participants for general clinical trials.
Recruitment method data, demographics, geographic location, and date of enrollment were collected from all 1,112 NLST participants. Marketing data and financial records were analyzed to determine the effectiveness of each recruitment method.
The total amount spent on advertising was $144,668, with the cost of enrollment per participant averaging $130. For black participants, the recruitment cost per person was $406, whereas for white and other race participants, the cost was $122 (P<0.0001). To encourage minority enrollment, $13,192 was spent on television advertising geared toward black viewers, resulting in eight black participants at an average cost per person of $1,649. Direct mailing cost $143 per participant recruited, whereas TV ads cost $382 per participant.
Direct mailing to a targeted group was the most efficient way to recruit participants. Printed advertising methods, that is, newspaper ads and brochures, were quite effective, whereas television ads were expensive. Appropriate minority recruitment needs sufficient attention and resources to ensure census groups are adequately represented.
分析维克森林大学医学院国家肺癌筛查试验（NLST）站点的广告、招募方法及研究参与者的人口统计学特征，以确定为一般临床试验招募参与者的有效方法。
收集了1112名NLST参与者的招募方法数据、人口统计学特征、地理位置及入组日期。分析营销数据和财务记录以确定每种招募方法的有效性。
广告总花费为144,668美元，每位参与者的平均招募成本为130美元。对于黑人参与者，每人的招募成本为406美元，而对于白人和其他种族参与者，成本为122美元（P<0.0001）。为鼓励少数族裔入组，花费13,192美元在面向黑人观众的电视广告上，招募到8名黑人参与者，平均每人成本为1,649美元。直接邮寄每位招募参与者的成本为143美元，而电视广告每位参与者成本为382美元。
向目标群体直接邮寄是招募参与者最有效的方式。印刷广告方法，即报纸广告和宣传册，相当有效，而电视广告成本高昂。适当的少数族裔招募需要足够的关注和资源，以确保各普查群体有充分的代表性。
