Zhang Kristine Y, Tung Bruce Y, Kowdley Kris V
Division of Gastroenterology and Hepatology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356424, Seattle, WA 98195, USA.
Clin Liver Dis. 2007 May;11(2):265-81. doi: 10.1016/j.cld.2007.04.002.
Liver transplantation has become an accepted treatment for several metabolic liver diseases. With advances in organ transplantation and immunosuppressive strategies, survival rates following liver transplantation are generally excellent. When the primary metabolic defect is hepatic in origin, liver transplantation not only replaces the dysfunctional organ but also cures the underlying metabolic defect. For conditions in which the primary metabolic defect is extrahepatic, liver transplantation is usually performed for hepatic complications, although disease recurrence may occur. This article reviews common metabolic liver diseases treated with liver transplantation in the adult population.
肝移植已成为多种代谢性肝病被认可的治疗方法。随着器官移植和免疫抑制策略的进展，肝移植后的生存率总体良好。当原发性代谢缺陷源于肝脏时，肝移植不仅替换了功能失调的器官，还治愈了潜在的代谢缺陷。对于原发性代谢缺陷在肝外的情况，尽管可能会出现疾病复发，但通常因肝脏并发症而进行肝移植。本文综述了在成年人群中采用肝移植治疗的常见代谢性肝病。
