西门塔尔牛的眼眶（球后）脑膜瘤。

Orbital (retrobulbar) meningioma in a Simmental cow.

作者信息

Reis J L, Kanamura C T, Machado G M, França R O, Borges J R J, Santos R L

机构信息

Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF, Brazil.

出版信息

Vet Pathol. 2007 Jul;44(4):504-7. doi: 10.1354/vp.44-4-504.

DOI:10.1354/vp.44-4-504

PMID:17606511

Abstract

A 12-year-old Simmental cow was presented with a moderately firm irregular whitish mass of approximately 5 cm in diameter, occupying the right orbit. Microscopically, a poorly differentiated neoplasm was observed. The immunohistochemical panel included cytokeratins, vimentin, epithelial membrane antigen, Factor VIII, CD34, Mart-1, Melan A, smooth muscle actin, desmin, chromogranin, neuron-specific enolase, S-100 protein, and MIB-1. The neoplasm was negative for all of them, with the exception of vimentin and S-100 protein. Transmission electron microscopy revealed abundant desmosomes. These findings support the diagnosis of orbital (retrobulbar) meningioma.

摘要

一头12岁的西门塔尔牛出现一个直径约5厘米、质地中等坚硬、不规则的白色肿物，占据右侧眼眶。显微镜下观察到一个低分化肿瘤。免疫组织化学检测项目包括细胞角蛋白、波形蛋白、上皮膜抗原、因子VIII、CD34、Mart-1、Melan A、平滑肌肌动蛋白、结蛋白、嗜铬粒蛋白、神经元特异性烯醇化酶、S-100蛋白和MIB-1。除波形蛋白和S-100蛋白外，肿瘤对所有检测项目均呈阴性。透射电子显微镜显示有大量桥粒。这些发现支持眼眶（球后）脑膜瘤的诊断。