Benvenuti Silvia, Comoglio Paolo M
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Candiolo (Torino), Italy.
J Cell Physiol. 2007 Nov;213(2):316-25. doi: 10.1002/jcp.21183.
Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its receptor RON.
各种细胞因子和可溶性生长因子与它们的膜受体相互作用后，负责诱导细胞增殖、分化、移动以及保护细胞免受失巢凋亡（一种由正常细胞在未附着于邻近细胞或细胞外基质（EMC）时激活的程序性自杀）。在这些可溶性因子中，肝细胞生长因子（HGF）与其受体MET以及巨噬细胞刺激蛋白（MSP）与其受体RON协同发挥主要作用。
