神经蛋白质组学的最新进展
Recent advances in neuroproteomics.
作者信息
Andrade Erika C, Krueger Dilja D, Nairn Angus C
机构信息
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA.
出版信息
Curr Opin Mol Ther. 2007 Jun;9(3):270-81.
Abstract
The last few years have seen a rapid growth in the use of proteomic methods to study normal brain function. In addition, such methods have been used to analyze changes in protein expression associated with the onset and progression of neuronal disease. The field of neuroproteomics faces special challenges given the complex cellular and sub-cellular architecture of the central nervous system. This article presents a review of recent progress in studies of neuroproteomics, and highlights the strengths and limitations of current proteomic profiling technologies used in studies of neuronal protein expression.
摘要
在过去几年中，蛋白质组学方法在研究正常脑功能方面的应用迅速增长。此外，这些方法已被用于分析与神经元疾病的发生和发展相关的蛋白质表达变化。鉴于中枢神经系统复杂的细胞和亚细胞结构，神经蛋白质组学领域面临着特殊的挑战。本文综述了神经蛋白质组学研究的最新进展，并强调了当前用于神经元蛋白质表达研究的蛋白质组分析技术的优势和局限性。
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