针对O-乙酰化肺炎球菌15B型荚膜多糖的功能性抗体与15C型血清型的交叉反应性较低。
Functional antibodies to the O-acetylated pneumococcal serotype 15B capsular polysaccharide have low cross-reactivities with serotype 15C.
作者信息
Rajam Gowrisankar, Carlone George M, Romero-Steiner Sandra
机构信息
Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
出版信息
Clin Vaccine Immunol. 2007 Sep;14(9):1223-7. doi: 10.1128/CVI.00184-07. Epub 2007 Jul 3.
Abstract
The 23-valent pneumococcal polysaccharide (Ps) vaccine offer protection against vaccine serotypes, but its cross-protection against vaccine-related serotypes is variable. We have demonstrated that the functional antibodies to serotype 15B are specific to the O-acetylated 15B-Ps and that they have low cross-reactivity with serotype 15C. Demonstration of functionally cross-reactive antibodies to vaccine-related serotypes is important for surveillance and vaccine development.
摘要
23价肺炎球菌多糖（Ps）疫苗可预防疫苗血清型，但它对疫苗相关血清型的交叉保护作用存在差异。我们已经证明，针对15B血清型的功能性抗体对O-乙酰化15B-Ps具有特异性，并且它们与15C血清型的交叉反应性较低。证明针对疫苗相关血清型的功能性交叉反应抗体对于监测和疫苗开发很重要。
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