Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.
Department of Pediatrics, The University of Melbourne , Melbourne, Australia.
Microbiol Spectr. 2024 Jan 11;12(1):e0357923. doi: 10.1128/spectrum.03579-23. Epub 2023 Dec 7.
(the pneumococcus) is a bacterial pathogen with the greatest burden of disease in Asia and Africa. The pneumococcal capsular polysaccharide has biological relevance as a major virulence factor as well as public health importance as it is the target for currently licensed vaccines. These vaccines have limited valency, covering up to 23 of the >100 known capsular types (serotypes) with higher valency vaccines in development. Here, we have characterized a new pneumococcal serotype, which we have named 33G. We detected serotype 33G in nasopharyngeal swabs ( = 20) from children and adults hospitalized with pneumonia, as well as healthy children in Mongolia. We show that the genetic, serological, and biochemical properties of 33G differ from existing serotypes, satisfying the criteria to be designated as a new serotype. Future studies should focus on the geographical distribution of 33G and any changes in prevalence following vaccine introduction.
（肺炎球菌）是一种在亚洲和非洲造成最大疾病负担的细菌病原体。肺炎球菌荚膜多糖具有生物学相关性，是一种主要的毒力因子，同时也具有重要的公共卫生意义，因为它是目前许可使用的疫苗的靶标。这些疫苗的效价有限，只能覆盖 100 多种已知荚膜型（血清型）中的 23 种，目前正在开发更高效价的疫苗。在这里，我们对一种新的肺炎球菌血清型进行了特征描述，我们将其命名为 33G。我们在因肺炎住院的儿童和成人的鼻咽拭子（= 20）以及蒙古的健康儿童中检测到了血清型 33G。我们表明，33G 的遗传、血清学和生化特性与现有血清型不同，符合被指定为新血清型的标准。未来的研究应集中在 33G 的地理分布以及疫苗接种后流行率的任何变化上。
