Stochholm Kirstine, Gravholt Claus Højbjerg, Laursen Torben, Laurberg Peter, Andersen Marianne, Kristensen Lars Østergaard, Feldt-Rasmussen Ulla, Christiansen Jens Sandahl, Frydenberg Morten, Green Anders
Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus, NBG, DK-8000 Aarhus C, Denmark.
Eur J Endocrinol. 2007 Jul;157(1):9-18. doi: 10.1530/EJE-07-0013.
To estimate the mortality in Denmark in patients suffering from GH deficiency (GHD).
Mortality was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in GHD patients were studied and additional morbidity noted. Patients were divided into childhood onset (CO) and adult onset (AO), discriminated by an age cutoff below or above 18 years at onset of GHD.
Data on death were identified in national registries. Sex- and cause-specific mortalities were identified in CO and AO GHD when compared with controls.
Mortality was increased in CO and AO GHD in both genders, when compared with controls. The hazard ratio (HR) for CO males was 8.3 (95% confidence interval (CI) 4.5-15.1) and for females 9.4 (CI 4.6-19.4). For AO males, HR was 1.9 (CI 1.7-2.2) and for females 3.4 (CI 2.9-4.0). We found a significantly higher HR in AO females versus AO males, both compared with controls (P < 0.001). In AO, mortality was increased due to cancer in all subgroups, due to circulatory diseases in all age groups for females and for males in the oldest age group. For CO, the increased mortality was due to cancer.
We found a significantly increased mortality in GHD patients when compared with controls, possibly due to their hypopituitary status. Mortality was increased in AO female patients when compared with males. For CO and AO GHD, different causes of significantly increased mortality were identified.
评估丹麦生长激素缺乏症（GHD）患者的死亡率。
对1794例GHD患者和8014例年龄及性别匹配的对照者的死亡率进行分析。研究了GHD患者的所有记录，并记录了其他发病率情况。根据GHD发病时年龄低于或高于18岁，将患者分为儿童期发病（CO）和成年期发病（AO）。
从国家登记处获取死亡数据。将CO和AO GHD患者与对照者进行比较，确定性别和病因特异性死亡率。
与对照者相比，CO和AO GHD患者的死亡率均升高。CO男性的风险比（HR）为8.3（95%置信区间（CI）4.5 - 15.1），女性为9.4（CI 4.6 - 19.4）。AO男性的HR为1.9（CI 1.7 - 2.2），女性为3.4（CI 2.9 - 4.0）。我们发现，与对照者相比，AO女性的HR显著高于AO男性（P < 0.001）。在AO患者中，所有亚组的癌症死亡率均升高，女性所有年龄组以及男性最年长年龄组的循环系统疾病死亡率升高。对于CO患者，死亡率升高是由于癌症。
我们发现与对照者相比，GHD患者的死亡率显著升高，可能是由于其垂体功能减退状态。与男性相比，AO女性患者的死亡率升高。对于CO和AO GHD患者，确定了死亡率显著升高的不同原因。
