Minguez F, Ramos C, Barrientos S, Loscos A, Prieto J
Department of Microbiology, Faculty of Medicine, Complutense University, Madrid, Spain.
Chemotherapy. 1991;37(6):420-5. doi: 10.1159/000238889.
The antimicrobial activity (minimal inhibitory concentration, MIC, and killing kinetics) and postantibiotic effect (PAE) of different concentrations (MIC and 6 mg/1) of ciprofloxacin, norfloxacin, ofloxacin, pefloxacin, fleroxacin and lomefloxacin on pure cultures of Staphylococcus aureus and Escherichia coli were compared in vitro. The MIC, killing kinetics and PAE were determined by standard methods. Ciprofloxacin displayed the lowest MICs, while the highest were those of norfloxacin against S. aureus and lomefloxacin against E. coli. The killing curves showed ciprofloxacin to be the most and norfloxacin the least active. The bactericidal power was dependent on the concentration. At MIC, the fluoroquinolones, with the exception of norfloxacin, induced PAEs of 1-2 h. The effect was, in all cases, greater against E. coli. When assayed at 6 mg/l the PAEs were increased to 2-5 h, the best results being obtained by ciprofloxacin followed by ofloxacin. Norfloxacin produced no PAE on S. aureus and scarcely reached 1.3 h against E. coli. There was a close relationship between bactericidal power and PAE.
在体外比较了不同浓度（最低抑菌浓度、MIC以及6毫克/升）的环丙沙星、诺氟沙星、氧氟沙星、培氟沙星、氟罗沙星和洛美沙星对金黄色葡萄球菌和大肠杆菌纯培养物的抗菌活性（最低抑菌浓度、MIC和杀菌动力学）及抗生素后效应（PAE）。通过标准方法测定MIC、杀菌动力学和PAE。环丙沙星的MIC最低，而诺氟沙星对金黄色葡萄球菌和洛美沙星对大肠杆菌的MIC最高。杀菌曲线显示环丙沙星活性最强，诺氟沙星活性最弱。杀菌力取决于浓度。在MIC时，除诺氟沙星外，氟喹诺酮类药物诱导的PAE为1至2小时。在所有情况下，对大肠杆菌的效应更大。当以6毫克/升进行测定时，PAE增加至2至5小时，环丙沙星效果最佳，其次是氧氟沙星。诺氟沙星对金黄色葡萄球菌未产生PAE，对大肠杆菌的PAE几乎未达到1.3小时。杀菌力与PAE之间存在密切关系。
