使用碱金属介导的金属化反应对氮杂环芳香化合物进行结构定义的直接碳-镁化和碳-锌化反应。
Structurally-defined direct C-magnesiation and C-zincation of N-heterocyclic aromatic compounds using alkali-metal-mediated metallation.
作者信息
Conway Ben, Hevia Eva, Kennedy Alan R, Mulvey Robert E
机构信息
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK G1 1XL.
出版信息
Chem Commun (Camb). 2007 Jul 19(27):2864-6. doi: 10.1039/b704362g. Epub 2007 May 4.
DOI:10.1039/b704362g
PMID:17609802
Abstract
Demonstrating direct synergic "low polarity metallation", 1-methylindole is C-magnesiated by (TMEDA)(2).Na(2)MgBu(4) and C-zincated by (TMEDA).Na((t)Bu)(TMP)Zn((t)Bu), and 1-methylpyrrole is C-zincated by the same reagent, with all three metal products successfully crystallographically characterised.
摘要
通过展示直接的协同“低极性金属化”，1-甲基吲哚被（TMEDA）₂·Na₂MgBu₄进行碳镁化反应，被（TMEDA）·Na⁺（t-Bu）（TMP）Zn（t-Bu）进行碳锌化反应，并且1-甲基吡咯也被相同的试剂进行碳锌化反应，所有三种金属产物均成功通过晶体学进行了表征。
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