McKinlay James B, Vieille C, Zeikus J Gregory
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA.
Appl Microbiol Biotechnol. 2007 Sep;76(4):727-40. doi: 10.1007/s00253-007-1057-y. Epub 2007 Jul 4.
Bio-based succinate is receiving increasing attention as a potential intermediary feedstock for replacing a large petrochemical-based bulk chemical market. The prospective economical and environmental benefits of a bio-based succinate industry have motivated research and development of succinate-producing organisms. Bio-based succinate is still faced with the challenge of becoming cost competitive against petrochemical-based alternatives. High succinate concentrations must be produced at high rates, with little or no by-products to most efficiently use substrates and to simplify purification procedures. Herein are described the current prospects for a bio-based succinate industry, with emphasis on specific bacteria that show the greatest promise for industrial succinate production. The succinate-producing characteristics and the metabolic pathway used by each bacterial species are described, and the advantages and disadvantages of each bacterial system are discussed.
生物基琥珀酸作为一种潜在的中间原料，有望取代大量基于石化产品的大宗化学品市场，因此受到越来越多的关注。生物基琥珀酸产业潜在的经济和环境效益推动了琥珀酸生产生物的研发。生物基琥珀酸仍面临着与基于石化产品的替代品竞争成本的挑战。必须以高产量生产高浓度琥珀酸，且副产物很少或没有，以便最有效地利用底物并简化纯化程序。本文介绍了生物基琥珀酸产业的当前前景，重点介绍了在工业琥珀酸生产中最具潜力的特定细菌。描述了每种细菌产生琥珀酸的特性和代谢途径，并讨论了每个细菌系统的优缺点。
